Regulation of TH17 cells in the mucosal surfaces

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Presentation transcript:

Regulation of TH17 cells in the mucosal surfaces Daniel Mucida, PhD, Shahram Salek-Ardakani, PhD Journal of Allergy and Clinical Immunology Volume 123, Issue 5, Pages 997-1003 (May 2009) DOI: 10.1016/j.jaci.2009.03.016 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Generation and regulation of TH17 responses in the intestine. Under the influence of microbial-derived stimuli and ATP, lamina propria (LP) CD70high and/or CD103- DCs induce TH17 differentiation through the production of TGF-β, IL-6, and IL-23. Production of TGF-β by LP cells also promotes the anti-inflammatory Foxp3+–induced T regulatory cells (iTreg). The balance between TH17 and Treg cell development is favored toward Treg cells on the influence of RA produced by LP and Peyer patch CD103+ DCs, LP macrophages, and IECs. Besides RA, TSLP expressed by IECs and the cytokine IL-25 were reported to suppress TH17 development in the intestine. Journal of Allergy and Clinical Immunology 2009 123, 997-1003DOI: (10.1016/j.jaci.2009.03.016) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions