Anti-glomerular basement membrane disease

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Anti-glomerular basement membrane disease Charles D. Pusey Kidney International Volume 64, Issue 4, Pages 1535-1550 (October 2003) DOI: 10.1046/j.1523-1755.2003.00241.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 (A) Low-power view of renal biopsy showing several cellular crescents at the same stage of evolution. There is dense interstitial infiltration with mononuclear cells (silver methenamine ×100). (B) High-power view of a glomerulus showing fibrinoid necrosis, breaks in the basement membrane, and crescent formation. Bowman's capsule is disrupted and there is periglomerular inflammation (silver methenamine ×200). (C) Immunohistology demonstrating linear deposition of IgG on the basement membrane in a glomerulus with a large crescent (immunoperoxidase ×200). Courtesy of Professor Terry Cook. Kidney International 2003 64, 1535-1550DOI: (10.1046/j.1523-1755.2003.00241.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Type IV collagen exists as a complex supramolecular network. Three individual α3(IV) chains are interwoven to form a triple helix, known as the protomer. The NC1 domains are arranged in a head-to-head fashion to form hexamers, and binding through the 7S domains completes the network structure. Hexamers can be dissociated to form dimers and monomers of NC1 domains, allowing identification of α3(IV)NC1 as the autoantigen. (redrawn with permission from [72]) Kidney International 2003 64, 1535-1550DOI: (10.1046/j.1523-1755.2003.00241.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 Long-term patient and renal survival in treated patients with anti-GBM disease. (A) Patient survival. The difference between patients with an initial creatinine concentration less than 500 μmol/L and the other groups was significant (P = 0.0055). (B) Renal survival. Only patients who did not require dialysis at presentation are included. The difference between the two groups was not significant. (redrawn with permission from [9]) Kidney International 2003 64, 1535-1550DOI: (10.1046/j.1523-1755.2003.00241.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Kidney International 2003 64, 1535-1550DOI: (10. 1046/j. 1523-1755 Kidney International 2003 64, 1535-1550DOI: (10.1046/j.1523-1755.2003.00241.x) Copyright © 2003 International Society of Nephrology Terms and Conditions