Writing Cochrane Protocol Cochrane Thailand Workshop 2017 Chumnan Kietpeerakool November 2017 Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Cochrane Protocol & Review: components of a protocol development Contact Managing Editor first to ask for the availability of the title of interest before developing the protocol Have to publish review protocol before developing a full review Title Registration Form (TRF) Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Cochrane Protocol & Review: components of a protocol development Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Cochrane Protocol & Review: components of a protocol development Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Software programs to be used for developing the protocol and review RevMan Covidence GRADEpro GDT Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Software programs to be used for developing the protocol and review RevMan Review Manager 5 (RevMan 5) is the software used for preparing and maintaining Cochrane Reviews. Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Covidence: What can you do in Covidence? Import citations Screen titles and abstracts Upload references Screen full text Create forms Risk of Bias Do Data extraction Export “When we discovered Covidence it was like an angel had come down from the sky!” Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Software programs to be used for developing the protocol and review GRADEpro GDT: an easy to use, all‐in‐one web solution to summarise and present information for healthcare decision making. Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: Background and objective Addressing the rationale for the review, and explaining the important of the questions being asked Should be concise (generally around one page when printed) and be understandable to the users of the intervention under investigation Citing all sources of information Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I Components of background Description of the condition Description of the intervention How the intervention might work Why it is important to do this review Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I Description of the condition How and where the condition occurs, affected group, diagnosis, symptoms and consequences A brief description of the condition being addressed and its significance Information about the biology, diagnosis, prognosis and public health impact (including prevalence or incidence) Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I Description of the intervention Providing a brief description of the intervention, including for whom it intended, its context in usual practice, comparison interventions, the treatment regimen or intervention components, and any known adverse effects For drugs, basic information on clinical pharmacology should be presented including dose range, metabolism, selective effects, half-life, duration and any known interactions with other drugs Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I How the intervention might work Describe the theoretical reasoning why the interventions under review may have an impact on potential recipients Refer to a body of empirical evidence such as similar interventions having an impact or identical interventions having an impact on other populations Refer to a body of literature that justifies the possibility of effectiveness Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I Why it is important to do this review Is there conflicting evidence? Have new RCTs recently been published? Is there any previous systematic review of this subject? Outline why this topic area is currently important Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I Objectives Beginning with a precise statement of the primary objective of the review, ideally in a single sentence Might be followed by a series of specific objectives relating to different participant groups, different comparisons of interventions or different outcome measures Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I The format should be as follows: To assess the effects of [intervention or comparison] for [health problem] for/in [types of people, disease or problem and setting if specified] OR To evaluate the effectiveness and safety of [intervention] for [disease] in [patients] To compare the effectiveness and safety of [intervention] with that of [state the comparison intervention] for [disease] in [patients] To evaluate the benefit and harms of different treatment modalities (offered in current practice?) for the management of [disease] in [patients] Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

Protocol Development: I Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence