Nomenclature and structural biology of allergens

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Presentation transcript:

Nomenclature and structural biology of allergens Martin D. Chapman, PhD, Anna Pomés, PhD, Heimo Breiteneder, PhD, Fatima Ferreira, PhD Journal of Allergy and Clinical Immunology Volume 119, Issue 2, Pages 414-420 (February 2007) DOI: 10.1016/j.jaci.2006.11.001 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Crystal structure of the cockroach allergen Bla g 2. Left, Structure of Bla g 2 showing residues at the region of the catalytic site (D215, D32 [1yg9.pdb]).19Right, The zinc ion (yellow sphere) with coordinating residues and interatomic distances (top) and aspartate positions in Bla g 2 (red aspartates on blue ribbon) and in pepsin (orange aspartates on yellow ribbon, bottom). Reprinted with permission from Gustchina A, Li M, Wunschmann S, Chapman MD, Pomés A, Wlodawer A. Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding protein with a novel mode of self-inhibition. J Mol Biol 2005;348:433-44.19 Journal of Allergy and Clinical Immunology 2007 119, 414-420DOI: (10.1016/j.jaci.2006.11.001) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Crystal structure of recombinant cat allergen Fel d 1 (1puo.pdb). Fel d 1 is a 2-chain heterodimer with the C-terminus of chain 1 (in gray) and the N-terminus of chain 2 (in white).21 The heterodimers associate together to form a larger dimeric structure. Also shown are various T-cell epitopes in chain 1 (IPC-1 and IPC-2) and chain 2 (P2:1 and P2:2). Journal of Allergy and Clinical Immunology 2007 119, 414-420DOI: (10.1016/j.jaci.2006.11.001) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Localization of Bla g 4 in the male cockroach reproductive system by means of in situ hybridization. Blue staining shows deposition of Bla g 4 among the reproductive tissues (left), with higher magnification of large apical utricles (U, upper right) and the conglobate gland (C, lower right). Reproduced with permission of Dr Coby Schal and Blackwells Scientific Publishing Company (Oxford, United Kingdom) from Fan et al.24CG, Conglobate gland; EP, ejaculatory pouch; ED, ejaculatory duct; MS, median sclerite; UG, uricose gland. Journal of Allergy and Clinical Immunology 2007 119, 414-420DOI: (10.1016/j.jaci.2006.11.001) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 From pollen to protein. A short ragweed pollen grain (left upper panel) and a series of purified recombinant allergens from short ragweed (lower left panel) analyzed by means of gel electrophoresis. Right, Three-dimensional structure of Amb a 1 modeled from the x-ray coordinates of Jun a 1, a pectate lyase from mountain cedar pollen. Journal of Allergy and Clinical Immunology 2007 119, 414-420DOI: (10.1016/j.jaci.2006.11.001) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions