Figure 2 Association of serum IgG reactivity with MRI measures of disease severity Association of serum IgG reactivity with MRI measures of disease severity.

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Figure 2 Association of serum IgG reactivity with MRI measures of disease severity Association of serum IgG reactivity with MRI measures of disease severity (A) Heatmap in which each column represents an MRI measure of either atrophy (BPF, GMF, WMF) or lesions (T2LV), and each row represents the correlation to IgG serum antibody reactivity according to a colorimetric scale. (B) Frequency of lipid-reactive antibodies linked to higher or lower MRI disease severity. BPF = whole brain parenchymal fraction; GMF = global cerebral gray matter fraction; IgG = immunoglobulin G; T2LV = cerebral T2 (fluid-attenuated inversion recovery) hyperintense lesion volume; WMF = global cerebral white matter fraction. Rohit Bakshi et al. Neurol Neuroimmunol Neuroinflamm 2016;3:e200 © 2016 American Academy of Neurology