Efficacy and Safety of a Once-Daily Morphine Formulation in Chronic, Moderate-to- Severe Osteoarthritis Pain Jacques R. Caldwell, MD, Ronald J. Rapoport,

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Presentation transcript:

Efficacy and Safety of a Once-Daily Morphine Formulation in Chronic, Moderate-to- Severe Osteoarthritis Pain Jacques R. Caldwell, MD, Ronald J. Rapoport, MD, Jeffrey C. Davis, MD, Howard L. Offenberg, MD, Howard W. Marker, MD, Sanford H. Roth, MD, William Yuan, PhD, Lise Eliot, PhD, Najib Babul, PharmD, Pia Mikkelsen Lynch, MD Journal of Pain and Symptom Management Volume 23, Issue 4, Pages 278-291 (April 2002) DOI: 10.1016/S0885-3924(02)00383-4

Fig. 1 Patient disposition in the double-blind trial. Journal of Pain and Symptom Management 2002 23, 278-291DOI: (10.1016/S0885-3924(02)00383-4)

Fig. 2 Sleep measures in the double-blind trial. Data are presented as Mean ± SE scored on a 100-mm VAS scale (0–100mm), with the exception of duration of sleep each night which is scored on a 12-pt scale (1 to 12 hr). For quality of sleep each night, positive values indicate an improvement. For trouble falling asleep due to Pain, Need for Sleep Medication, and Awakenings During the Night and Morning due to Pain, negative values indicate an improvement. *Statistically significant (p ≤ 0.05) difference versus placebo. †Statistically significant (p ≤ 0.05) difference versus MSC twice daily. Journal of Pain and Symptom Management 2002 23, 278-291DOI: (10.1016/S0885-3924(02)00383-4)

Fig. 3 Patient disposition in the open-label trial. Journal of Pain and Symptom Management 2002 23, 278-291DOI: (10.1016/S0885-3924(02)00383-4)

Fig. 4 Efficacy in the open-label trial. Efficacy data are presented as Mean changes ± SE from baseline (Week 4). Dose data presented as Mean ± SE, which represents the dose at the time of the efficacy assessments. *Statistically significant differences in efficacy assessments from baseline (Week 4) for both Avinza QAM and QPM (p ≤ 0.05). WOMAC OA Index Pain (0–500 mm), Overall Arthritis Pain Intensity (0–100 mm) and WOMAC Physical Function (0–1,700 mm), WOMAC Stiffness (0–200 mm). Journal of Pain and Symptom Management 2002 23, 278-291DOI: (10.1016/S0885-3924(02)00383-4)