Familial Hypercholesterolemia – Genetic disease from a mutation of the LDL receptor (doesn’t remove LDL from circulation)

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Presentation transcript:

Familial Hypercholesterolemia – Genetic disease from a mutation of the LDL receptor (doesn’t remove LDL from circulation)

ATP used to Initiate β-oxidation

Page 746

NADPH

Cascade for Biosynthesis of Eicosanoids 2

Biosynthesis of Eicosanoids Mammals (unsaturation anabolism) C9 Plants (unsaturation anabolism) Arachadonic Acid (ω-6) Cleaved from phospholipids via a phospholipase Cyclooxygenases Prostaglandins (thromboxanes) Leukotrienes 3

COX catalyzed reaction 4

COX Inhibitors 5

COX Inhibitors 5

Aspirin – Mode of Action 6