Aaron M. Abarbanell, MD, Arthur C. Coffey, MD, John W

Slides:

Advertisements

Similar presentations

Changes in Risk Profile Over Time in the Population of a Pediatric Heart Transplant Program Olaf Reinhartz, MD, Katsuhide Maeda, MD, Bruce A. Reitz, MD,

Advertisements

Jeffrey M. Griffin, MD, MS, Carolyn E. Reed, MD, Chadrick E

Targeting Immune Checkpoints in Esophageal Cancer: A High Mutational Load Tumor Rajeev Dhupar, MD, Lauren Van Der Kraak, PhD, Arjun Pennathur, MD, Matthew.

Stem Cell Engraftment and Survival in the Ischemic Heart

What Predicts Long-Term Survival After Heart Transplantation

Kaviyanka Selvasandran, MS, Georges Makhoul, MD, MS, Prashant K

Giant Transdiaphragmatic Intercostal Hernia

High-mobility group box-1 protein induces osteogenic phenotype changes in aortic valve interstitial cells Bo Wang, PhD, Fei Li, MD, Chao Zhang, PhD,

The STS National Database

Sirtuin1 Regulates the Stem Cell Therapeutic Effects on Regenerative Capability for Treating Severe Heart Failure in a Juvenile Animal Model Hideto Ozawa,

Liver regeneration Journal of Hepatology

The surgeon's role in molecular biology

Kanika Trehan, MD, Xun Zhou, MD, Stephen C. Yang, MD

Toll-like receptor activation: from renal inflammation to fibrosis

Functional Roles of Tumor Necrosis Factor-Alpha and Interleukin 1-Beta in Hypoxia and Reoxygenation Heather E. Merry, MD, Patrick Phelan, MD, Matthew.

Targeting Immune Checkpoints in Esophageal Cancer: A High Mutational Load Tumor Rajeev Dhupar, MD, Lauren Van Der Kraak, PhD, Arjun Pennathur, MD, Matthew.

Bryan A. Whitson, MD, Blake A

Lisa M. Brown, MD, MAS, David T. Cooke, MD, Elizabeth A. David, MD

Georges Makhoul, MD, MS, Ray C.J. Chiu, MD, PhD, Renzo Cecere, MD, MS

P38 Mitogen Activated Protein Kinase Mediates Both Death Signaling and Functional Depression in the Heart Meijing Wang, MD, Ben M. Tsai, MD, Mark W.

Craig H Selzman, MD, Stephanie A Miller, MD, Alden H Harken, MD

Cytokines Link Toll-Like Receptor 4 Signaling to Cardiac Dysfunction After Global Myocardial Ischemia John Cha, MD, Zhiping Wang, MD, Lihua Ao, BS, Ning.

Invited Commentary The Annals of Thoracic Surgery

Total Arch Replacement Under Normothermic Beating Heart Surgery

Denton A. Cooley, August 22, 1920, to November 18, 2016

Michael G. Katz, MD, PhD, Anthony S. Fargnoli, PhD, Andrew P

Expression of Bone Morphogenetic Proteins in Human Lung Carcinomas

Potential Molecular Mechanism of Retrograde Aortic Arch Stenosis in the Hybrid Approach to Hypoplastic Left Heart Syndrome Narutoshi Hibino, MD, Mary.

Daniel R. Meldrum, MD, Brian D

Do Statins Have a Role in the Promotion of Postoperative Wound Healing in Cardiac Surgical Patients? Gerard J. Fitzmaurice, MRCSI, MS, Billy McWilliams,

Surgical Resection of a Giant Coronary Aneurysm

Late Presentation of a Right Bochdalek Hernia With Intrathoracic Liver, Gallbladder, Intestines and Omentum With Right Lower Lobe Hypoplasia Mohammad.

Public policy and the practicing physician

Successful Use of Recombinant Activated Coagulation Factor VII in a Patient with Massive Hemoptysis From a Penetrating Thoracic Injury Homer C.N. Tien,

William T. Mahle, MD, Emilia Matthews, MS, Kirk R. Kanter, MD, Brian E

Origins of the Cardiothoracic Surgery Network (CTSNet)

Who Do You Say You Are? The Annals of Thoracic Surgery

Surgical Treatment of Atrial Fibrillation: The Time Is Now

Use of Amiodarone After Major Lung Resection

Surgical Dilemmas: Diagnosis and Treatment of Atrial Plasmacytoma

Modified Ross Procedure to Prevent Autograft Dilatation

Kuthan Kavakli, MD, Deniz Dogan, MD, Sedat Gurkok

Abel Gómez-Caro, MD, Pedro Arguis, MD The Annals of Thoracic Surgery

Courtney N. Zeller, Yue Wang, PhD, Troy A

Expression of vascular endothelial growth factor in thoracic sarcomas

Embolized Methyl Methacrylate to the Right Atrium After Kyphoplasty

Complementary Alternative Medical Therapies for Heart Surgery Patients: Feasibility, Safety, and Impact Vibhu R. Kshettry, MD, Linda Flies Carole, PsyD,

Editorial Board, January 2010

Completely Thrombosed Tricuspid Pouch Mimicking a Cardiac Tumor

The Annals of Thoracic Surgery

An Unusual Cause of Hemoptysis in a Young Woman

Deterioration of a Tricuspid Bioprosthesis Due to Adhesion of the Native Valve Herbert Gutermann, MD, Willem Flameng, MD, PhD, Paul Herijgers, MD, PhD

The Unifocal Bilateral Bidirectional Cavopulmonary Anastomosis

Acute Esophageal Necrosis: A Case Series and Long-Term Follow-Up

Dana Y. Fuhrman, DO, MS, Lan G

Invited Commentary The Annals of Thoracic Surgery

Functional and Physiologic Results of Video-Assisted Thoracoscopic Diaphragm Plication in Adult Patients With Unilateral Diaphragm Paralysis Richard.

Robert Lee Replogle, September 30, 1931–May 9, 2016

Digital Drainage System Reduces Hospitalization After Video-Assisted Thoracoscopic Surgery Lung Resection Daniel L. Miller, MD, Gerald A. Helms, MD,

A Target for Perioperative Blood Pressure During Cardiac Operations

The American Board of Thoracic Surgery: Update

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

Endothelial Cell Injury in Cardiovascular Surgery

Rachael L. Ford, BS, Ira M. Mains, BS, Ebony J. Hilton, BS, Scott T

Mark I. Block, MD The Annals of Thoracic Surgery

Late Consequences of a Much Earlier Decision

The Impact of New Technology on Cardiothoracic Surgical Practice

Heart Transplant Program Volume Is Not a Measure of Quality

J. Alberto Lopez, MD The Annals of Thoracic Surgery

David S. Mulder, MD The Annals of Thoracic Surgery

Presentation transcript:

Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart Aaron M. Abarbanell, MD, Arthur C. Coffey, MD, John W. Fehrenbacher, MD, Daniel J. Beckman, MD, Jeremy L. Herrmann, MD, Brent Weil, MD, Daniel R. Meldrum, MD The Annals of Thoracic Surgery Volume 88, Issue 3, Pages 1036-1043 (September 2009) DOI: 10.1016/j.athoracsur.2009.02.093 Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Selected cytokines and associated pathways that affect mesenchymal stem cell (MSC) function. Multiple cytokines alter MSC function. The known receptors and pathways are shown. Based on the known research, it is likely that crosstalk exists at multiple intracellular levels. (HGF = hepatocyte growth factor; HMGB1 = high mobility group box 1; IGF-1 = insulin-like growth factor-1; MET = mesenchymal-epithelial transition factor receptor; NF-κB = nuclear factor kappa-B; RAGE = receptor for advanced glycation end products; TGF-β1 = transforming growth factor-beta 1; TLR = toll-like receptor; TNF = tumor necrosis factor; TNFR1 = tumor necrosis factor receptor 1; TNFR2 = tumor necrosis factor receptor 2; VEGF = vascular endothelial growth factor.) The Annals of Thoracic Surgery 2009 88, 1036-1043DOI: (10.1016/j.athoracsur.2009.02.093) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Schematic of three targets that modulate the effects of cytokines on mesenchymal stem cell (MSC) function. Cytokines affect MSC function. The effects of cytokine stimuli can be augmented or repressed at the receptor level or at the intracellular level in MSCs. Alternatively, MSCs can be modified to overexpress cytokines that may affect MSC function in vivo. The Annals of Thoracic Surgery 2009 88, 1036-1043DOI: (10.1016/j.athoracsur.2009.02.093) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions