Metabolic effects of K107R and rosiglitazone treatment.

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Metabolic effects of K107R and rosiglitazone treatment. Metabolic effects of K107R and rosiglitazone treatment. (A–E) Metabolic parameters were measured in plasma from DIO WT and K107R mice treated with vehicle (veh) or rosiglitazone (rosi) for 7 d by oral gavage. Blood was collected from the tail veins of 4-h–fasted mice to measure insulin and glucose or from the cardiac ventricle to measure other parameters. n = 6 mice per group. *P < 0.05; **P < 0.01; ***P < 0.001. (F and G) Plasma insulin (F) and glucose (G) concentrations during an i.p. glucose tolerance test in DIO WT and K107R mice treated with vehicle or rosiglitazone for 7 d by oral gavage. n = 6 mice per group. *P < 0.05; **P < 0.01; ***P < 0.001 compared with WT/veh mice. (H) Plasma glucose concentrations during an i.p. insulin tolerance test in DIO WT and K107R mice treated with vehicle or rosiglitazone for 7 d by oral gavage. n = 6 mice per group. Takeshi Katafuchi et al. PNAS 2018;115:48:12102-12111 ©2018 by National Academy of Sciences