Management of NGS data or tests in oncology healthdata.be Management of NGS data or tests in oncology 2nd Symposium “ Introduction of the Next-Generation-sequencing technology in routine clinical analysis in the Belgian healthcare “ Sponsored by 2017.11.07, Passage 44, Brussels

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Roadmap “Next Generation Sequencing” started Q1 2016: Main focus of project = quality of NGS testing (KC) , secondary focus on epidemiology (BCR) Precision Belgium project by the Belgian Society of Medical Oncology (BSMO) : in close collaboration with project team Roadmap “Next Generation Sequencing”: VCF-files will be used for inclusion patients in existing and new clinical trials of the BSMO. Predictive Tests For A Therapeutic Response (PITTER): Main focus of project to collect epidemiological and outcome data on reimbursed tests and medicines, in order to assess and modify national recommendations and reimbursement policies.

Healthdata.be at a glance Technical description of each data collection healthdata.be HD4DP HD4RES DATAWAREHOUSE HEALTHSTAT HD4DP = software “healthdata for data providers” HD4RES = software “healthdata for researchers” HD4PrC = software / API “healthdata for primary care” HD4PrC = software “healthdata for patient reported outcomes” API = “Application Programming Interface” (cfr. “Webservice”)          Registration in Primary System Data Captation Secure Data Transfer & encoding of IDs Data Monitoring Data Validation Data Storage Analysis BI-Reporting Annotation & Correction Request Trusted Third Party for encryption and pseudonymization

100% (of 117) 100% (of 9) 92% (of 87) 88% (of 150) hospitals Lab genetics Lab Ana Path Lab Clin Bio

DCD’s Final: n = 28 DCD’s draft: n= 12 Data Collection Definitions (DCD’s): list view

Data Collection Definitions (DCD’s): full description

DEMO environment: main portal

DEMO environment: NGS form example

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Roadmap NGS PRECISION Belgium PITTER HD4DP DCD TPR DWH HD SteerCo Sect Comm 01.2018 HD4DP DCD TPR DWH HD SteerCo Sect Comm 01.2018 Roadmap NGS HD4DP DCD TPR DWH HD SteerCo Sect Comm 01.2018 PRECISION Belgium PITTER

Think big, start small SAM/BAM-files FASTA-files VCF-files Ongoing analysis of requirements and available technologies for transfer, management and analysis. First decisions and implementtions expected in 2018. Start 01.2018

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