M Rollandet al. Nature 000, 1-4 (20120) doi:10.1038/nature11519 Phylogenetic tree ofenv-V1/V2 nucleotide sequences with highlights for sequences presentingmutations at either site 169 (in pink) or 181 (in yellow) or at both sites (in grey). Sequences from vaccine recipients are figured in red, those from placebo recipients are in blue. M Rollandet al. Nature 000, 1-4 (20120) doi:10.1038/nature11519 Note: This figure is from a near-final version AOP and may change prior to final publication in print/online