Evaluation of serum s-IgE/total IgE ratio in predicting clinical response to allergen- specific immunotherapy Gabriele Di Lorenzo, MD, Pasquale Mansueto,

Slides:

Advertisements

Similar presentations

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

Advertisements

Detection of novel occupational wood allergens in locust wood dust (Robinia pseudoacacia L.) Sabine Kespohl, PhD, Rolf Merget, MD, Axel Overlack, MD,

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

The natural history of soy allergy

Evaluation of serum s-IgE/total IgE ratio in predicting clinical response to allergen- specific immunotherapy Gabriele Di Lorenzo, MD, Pasquale Mansueto,

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Allergen immunotherapy: A practice parameter third update

Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE Elizabeth A. Erwin,

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Three years of specific immunotherapy may be sufficient in house dust mite respiratory allergy Ana I. Tabar, MD, PhD, Esozia Arroabarren, MD, Susana.

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Major rabbit allergen Ory c 3: What could be its possible role as a sensitizing agent in real life? Gennaro Liccardi, MD, Antonello Salzillo, MD, Maria.

Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: A meta-analysis–based comparison Danilo Di.

Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood Zaraquiza Zolkipli, MSc,

Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD

Diagnosis of red meat allergy with antigen-specific IgE tests in serum

Is 9 more than 2 also in allergic airway inflammation?

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

BCG vaccination and allergy: A systematic review and meta-analysis

Allergy testing in predicting outcome of open food challenge to peanut

Simultaneous detection of total and allergen-specific IgE by using purified allergens in a fluorescent multiplex array Eva-Maria King, PhD, Lisa D. Vailes,

Peter M. Wolfgram, MD, David B. Allen, MD

Etiology of asthma exacerbations

IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life

Reply Journal of Allergy and Clinical Immunology

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

Phillip Lieberman, MD, Michael Tankersley, MD

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Genetically engineered hybrid proteins from Parietaria judaica pollen for allergen- specific immunotherapy Roberto González-Rioja, PhD, Ignacio Ibarrola,

Phillip Lieberman, MD, David Golden, MD

Modulating allergic response by engineering the major Parietaria allergens Angela Bonura, PhD, Daniela Di Blasi, PhD, Bianca Barletta, PhD, Cinzia Butteroni,

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Christian Hennig, MD, Christine Happle, MD, Gesine Hansen, MD

Allergen-specific immunotherapy with recombinant grass pollen allergens Marek Jutel, MD, Lothar Jaeger, MD, Roland Suck, PhD, Hanns Meyer, Dipl Math,

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

What is an “eosinophilic phenotype” of asthma?

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

House dust mite sublingual immunotherapy: Results of a US trial

Is intralymphatic immunotherapy ready for clinical use in patients with grass pollen allergy? Marianne Witten, MD, PhD, Hans-Jørgen Malling, MD, Lars.

Syk expression and IgE-mediated histamine release in basophils as biomarkers for predicting the clinical efficacy of omalizumab Donald W. MacGlashan,

Local allergic rhinitis: Allergen tolerance and immunologic changes after preseasonal immunotherapy with grass pollen Carmen Rondón, MD, PhD, Natalia.

One step forward, 2 steps back: The enigma of preschool wheeze

Risk of oral food challenges

Eosinophilic esophagitis treated with immunotherapy to dust mites

Reply Journal of Allergy and Clinical Immunology

Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis Carmen Rondón, MD, PhD, Javier.

Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis Philippe-Jean Bousquet, MD, Christophe Combescure, PhD,

Efficacy and safety of sublingual tablets of house dust mite allergen extracts: Results of a dose-ranging study in an environmental exposure chamber

Pedro Gamboa, MD, PhD, Rosa Sanchez-Monge, PhD, M

Thunderstorm-related asthma attacks

Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens Riikka Uotila, MD, Anna.

Jessica H. Savage, MD, MHS, Elizabeth C. Matsui, MD, MHS, Robert A

Measles and immunomodulation

Asthma progression: Can we and should we measure it?

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis Andrea L. Jones, MD, Douglas Curran-Everett, PhD,

Environmental factors and eosinophilic esophagitis

The GILL study: Glycerin-induced local reactions in immunotherapy

The effects of an H3 receptor antagonist (PF ) with fexofenadine on reducing allergic rhinitis symptoms Jeffrey R. Stokes, MD, Francisco A. Romero,

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Presentation transcript:

Evaluation of serum s-IgE/total IgE ratio in predicting clinical response to allergen- specific immunotherapy Gabriele Di Lorenzo, MD, Pasquale Mansueto, MD, Maria Luisa Pacor, MD, Manfredi Rizzo, MD, Francesco Castello, MD, Nicola Martinelli, MD, Vito Ditta, MD, Claudia Lo Bianco, MD, Maria Stefania Leto-Barone, MD, Alberto D'Alcamo, MD, Gaetana Di Fede, MD, Giovam Battista Rini, MD, Anne Marie Ditto, MD Journal of Allergy and Clinical Immunology Volume 123, Issue 5, Pages 1103-1110.e4 (May 2009) DOI: 10.1016/j.jaci.2009.02.012 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 ROC curves obtained with serum t-IgE levels (decision point, ≤133 kU/L; sensitivity, 69.7%; and specificity, 67.9%), serum s-IgE levels (decision point, 9.5 kAU/L; sensitivity, 91.0%; specificity, 46.3%), b-eos counts (decision point, 0.43 cells × 10−3 μL; sensitivity, 87.6%; specificity, 57.5%), and serum s-IgE/serum t-IgE ratios (decision point, 16.2%; sensitivity, 97.2%; specificity, 88.1%) by plotting sensitivity in patients with an effective response to ASI versus 100-specificity in patients with an ineffective response to ASI. Journal of Allergy and Clinical Immunology 2009 123, 1103-1110.e4DOI: (10.1016/j.jaci.2009.02.012) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Sensitivity (Sens) and specificity (Spec) calculated for each allergen used for ASI by using the ratio of serum s-IgE/serum t-IgE of 16.2% as the decision point. A, grass; B, Parietaria judaica; C, Olea europa; D, house dust mites (HDM). Journal of Allergy and Clinical Immunology 2009 123, 1103-1110.e4DOI: (10.1016/j.jaci.2009.02.012) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Graphic representation of means of VAS (± SD) with regard to A, rhinitis and B, asthma symptoms, respectively. Journal of Allergy and Clinical Immunology 2009 123, 1103-1110.e4DOI: (10.1016/j.jaci.2009.02.012) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions