Figure 1 Schematic overview of the LGI1 protein in the synapse

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Figure 1 Schematic overview of the LGI1 protein in the synapse Figure 1 | Schematic overview of the LGI1 protein in the synapse. a | Leucine-rich glioma-inactivated 1 (LGI1) dimers bind to presynaptic ADAM23 (a disintegrin and metalloproteinase 23) and postsynaptic ADAM22. This structure regulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and voltage-gated potassium channel (VGKC) currents. b | Patients' antibodies bind to LGI1 and are presumed to alter neuronal excitability. PSD95, disks large homologue 4. van Sonderen, A. et al. (2017) The value of LGI1, Caspr2 and voltage-gated potassium channel antibodies in encephalitis Nat. Rev. Neurol. doi:10.1038/nrneurol.2017.43