The effects of calcitriol treatment in glucocorticoid-resistant asthma

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Presentation transcript:

The effects of calcitriol treatment in glucocorticoid-resistant asthma Alexandra M. Nanzer, MRCP, Emma S. Chambers, PhD, Kimuli Ryanna, MRCP, Anna T. Freeman, MRCP, Grainne Colligan, BSc, David F. Richards, MSc, Peter M. Timms, FRCPath, Adrian R. Martineau, PhD, Christopher J. Griffiths, FRCGP, Christopher J. Corrigan, PhD, Catherine M. Hawrylowicz, PhD Journal of Allergy and Clinical Immunology Volume 133, Issue 6, Pages 1755-1757.e4 (June 2014) DOI: 10.1016/j.jaci.2014.03.015 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Treatment with calcitriol or vitamin D sufficiency improves clinical response to steroids. A, Comparison of change in (i) absolute lung function (FEV1 [L]) and (ii) predicted lung function after a 2-week course of prednisolone at screening (pretreatment) and treatment (together with placebo OR calcitriol). B, Serum 25(OH)D levels of the placebo group at the beginning as compared with the last visit of the clinical trial. C, Correlation between serum 25(OH)D and change in lung function (predicted %) after a 2-week course of prednisolone during the treatment phase of the trial (after placebo treatment). D, Comparison of change in predicted lung function after a 2-week course of prednisolone at screening (pretreatment) and treatment (together with placebo treatment) in those defined as high serum 25(OH)D (closed squares; >50 nmol/L) or low serum 25(OH)D (open circles; <50 nmol/L); data shown as median ± interquartile range. Journal of Allergy and Clinical Immunology 2014 133, 1755-1757.e4DOI: (10.1016/j.jaci.2014.03.015) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Schematic of clinical trial design. Journal of Allergy and Clinical Immunology 2014 133, 1755-1757.e4DOI: (10.1016/j.jaci.2014.03.015) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions