Eosinophil extracellular DNA traps in skin diseases

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Presentation transcript:

Eosinophil extracellular DNA traps in skin diseases Dagmar Simon, MD, Susanne Hoesli, MD, Nina Roth, Simon Staedler, Shida Yousefi, PhD, Hans-Uwe Simon, MD, PhD Journal of Allergy and Clinical Immunology Volume 127, Issue 1, Pages 194-199 (January 2011) DOI: 10.1016/j.jaci.2010.11.002 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Eosinophil extracellular traps (arrows). Accumulation of eosinophils releasing DNA (red) and ECP (green) in BP. DNA plus ECP, overlay (A), DNA (B), ECP (C). Journal of Allergy and Clinical Immunology 2011 127, 194-199DOI: (10.1016/j.jaci.2010.11.002) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Release of ECP by eosinophils. A, A single eosinophil generating an EET consisting of DNA (red) and ECP (green) in larva migrans. B, Broad fibrous structures covered with ECP (green) forming a flame figure in WS. C, EETs (arrows) and eosinophil granule depositions with ECP (green; arrowheads) in WS. DNA was stained with PI (red). Magnification ×1000. Journal of Allergy and Clinical Immunology 2011 127, 194-199DOI: (10.1016/j.jaci.2010.11.002) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 IL-5 and eotaxin–expressing cells in skin tissues containing EETs. A, IL-5–expressing (green) and CD4-positive (red) cells in APT. Double-positive cells (yellow) are indicated by arrows, single IL-5–expressing cells (green) by arrowheads. Single CD4-positive cells (red) are also visible. B, Eotaxin-2–positive cells in BP. Eosinophils (arrows) and noneosinophilic cells (arrowhead) express eotaxin-2. Journal of Allergy and Clinical Immunology 2011 127, 194-199DOI: (10.1016/j.jaci.2010.11.002) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Cleaved caspase-3 expression and EETs in BP. A, Caspase-3–positive cells throughout the epidermis, beneath eosinophils (arrows) in the dermis. Nuclei were counterstained with PI. B-D, Eosinophil at the dermal-epidermal junction (dashed line) generating an EET (arrow). DNA plus ECP, overlay (B), DNA (C), ECP (D). Magnification ×400 (A), ×1000 (B-D). Journal of Allergy and Clinical Immunology 2011 127, 194-199DOI: (10.1016/j.jaci.2010.11.002) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions