Live birth after ovarian tissue autograft in a patient with sickle cell disease treated by allogeneic bone marrow transplantation Christophe Roux, M.D.,

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Presentation transcript:

Live birth after ovarian tissue autograft in a patient with sickle cell disease treated by allogeneic bone marrow transplantation Christophe Roux, M.D., Ph.D., Clotilde Amiot, M.D., Ph.D., Germain Agnani, M.D., Yves Aubard, M.D., Ph.D., Pierre-Simon Rohrlich, M.D., Ph.D., Pascal Piver, M.D. Fertility and Sterility Volume 93, Issue 7, Pages 2413.e15-2413.e19 (May 2010) DOI: 10.1016/j.fertnstert.2009.12.022 Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Time line of treatment. (B) Histology of ovarian cortical strip after freezing and thawing, showing healthy primordial and primary follicles. (C) Histology of the biopsy sample of the remaining left ovary before autograft: no follicle present. Bars for B,C = 500 μm. (D) Hormone profile: FSH (UI/L), LH (UI/L), and anti-Müllerian hormone (AMH) (pmol/L). Nine weeks (day 63) after reimplantation, restoration of endocrine ovarian function was shown by assessment of hormone concentrations: a decrease of FSH and LH levels and an increase of AMH. Arrow: day of autograft; arrowhead: time hormone replacement therapy (HT) stopped. Fertility and Sterility 2010 93, 2413.e15-2413.e19DOI: (10.1016/j.fertnstert.2009.12.022) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 2 (A) The LH, E2, and P concentrations, 5 months after ovarian graft. The monitored natural cycle showed an LH peak before ovulation (day 17), an increase in E2 concentration during folliculogenesis, and a P increase in the luteal phase. (B, C) Vaginal ultrasonographic examination, performed at day 14 of the monitored cycle, demonstrated one follicle (18.5 mm in size D1) in the peritoneal right side (B) and three follicles (12.2 mm D1; 8.5 mm D2; 8.6 mm in size D3) on the left on the ovarian side (C). Fertility and Sterility 2010 93, 2413.e15-2413.e19DOI: (10.1016/j.fertnstert.2009.12.022) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions