Jessica J. Lin, MD, Lauren L. Ritterhouse, MD, PhD, Siraj M

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ROS1 Fusions Rarely Overlap with Other Oncogenic Drivers in Non–Small Cell Lung Cancer Jessica J. Lin, MD, Lauren L. Ritterhouse, MD, PhD, Siraj M. Ali, MD, PhD, Mark Bailey, MS, Alexa B. Schrock, PhD, Justin F. Gainor, MD, Lorin A. Ferris, BA, Mari Mino-Kenudson, MD, PhD, Vincent A. Miller, MD, Anthony J. Iafrate, MD, PhD, Jochen K. Lennerz, MD, PhD, Alice T. Shaw, MD, PhD Journal of Thoracic Oncology Volume 12, Issue 5, Pages 872-877 (May 2017) DOI: 10.1016/j.jtho.2017.01.004 Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 ROS1 rearrangements are generally mutually exclusive with oncogenic driver alterations in EGFR, KRAS, and anaplastic lymphoma receptor tyrosine kinase gene (ALK). One case (patient 53) in the Massachusetts General Hospital cohort had ROS1 testing results that were positive by fluorescence in situ hybridization (FISH) (dark gray) but negative by next-generation sequencing (NGS) (purple). This case was found to harbor a KRAS G13D mutation (red) and an EGFR C781F mutation of unknown significance (blue). Another case (patient 48) had a KRAS I24N mutation of unknown significance (blue). All other ROS1-rearranged NSCLC cases in the Massachusetts General Hospital cohort tested negative (white) for concurrent EGFR and KRAS mutations and ALK rearrangements. Journal of Thoracic Oncology 2017 12, 872-877DOI: (10.1016/j.jtho.2017.01.004) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions