Ground glass opacities: Imaging, pathology, and gene mutations

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Presentation transcript:

Ground glass opacities: Imaging, pathology, and gene mutations Fenghao Sun, MD, Junjie Xi, MD, Cheng Zhan, PhD, Xiaodong Yang, MD, Lin Wang, MD, Yu Shi, MD, Wei Jiang, MD, Qun Wang, MD The Journal of Thoracic and Cardiovascular Surgery Volume 156, Issue 2, Pages 808-813 (August 2018) DOI: 10.1016/j.jtcvs.2018.02.110 Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Predominant subtypes in both groups. AAH, Atypical adenomatous hyperplasia; AIS, adenocarcinoma in situ; MIA, microinvasive adenocarcinoma; D, diameter. The Journal of Thoracic and Cardiovascular Surgery 2018 156, 808-813DOI: (10.1016/j.jtcvs.2018.02.110) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 All pathologic subtypes in both groups. AAH, Atypical adenomatous hyperplasia; AIS, adenocarcinoma in situ; MIA, microinvasive adenocarcinoma; D, diameter. The Journal of Thoracic and Cardiovascular Surgery 2018 156, 808-813DOI: (10.1016/j.jtcvs.2018.02.110) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Gene mutation pattern in both groups. B-RAF, B-rapidly accelerated fibrosarcoma; EGFR, epidermal growth factor receptor; HER-2, human epidermal growth factor receptor 2; K-RAS, Kirsten rat sarcoma viral oncogene homolog; RET, ret proto-oncogene; ROS-1, c-ros oncogene 1 receptor tyrosine kinase; D, diameter; ALK, anaplastic lymphoma kinase; PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. The Journal of Thoracic and Cardiovascular Surgery 2018 156, 808-813DOI: (10.1016/j.jtcvs.2018.02.110) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 EGFR mutation site in both groups. EGFR, Epidermal growth factor receptor; D, diameter. The Journal of Thoracic and Cardiovascular Surgery 2018 156, 808-813DOI: (10.1016/j.jtcvs.2018.02.110) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Correlation between the predominant pathologic subtype and EGFR mutation rate. EGFR, Epidermal growth factor receptor; AIS, adenocarcinoma in situ; MIA, microinvasive adenocarcinoma. ***P < .001; #P > .05. The Journal of Thoracic and Cardiovascular Surgery 2018 156, 808-813DOI: (10.1016/j.jtcvs.2018.02.110) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

All pathologic subtypes in both groups. The Journal of Thoracic and Cardiovascular Surgery 2018 156, 808-813DOI: (10.1016/j.jtcvs.2018.02.110) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Video 1 Segmentectomy of left upper lobe S1 + 2 + 3. Video available at: https://www.jtcvs.org/article/S0022-5223(18)30941-3/fulltext. The Journal of Thoracic and Cardiovascular Surgery 2018 156, 808-813DOI: (10.1016/j.jtcvs.2018.02.110) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions