Toll-like Receptor 9, What O'Clock Is It?

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Toll-like Receptor 9, What O'Clock Is It? Hannah-Lena Obermann, Stefan Bauer  Immunity  Volume 36, Issue 2, Pages 159-161 (February 2012) DOI: 10.1016/j.immuni.2012.02.003 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Influence of Oscillating TLR9 Function on Timing of Therapeutic Intervention Gene expression is regulated via the master clock in the hypothalamus, the suprachiasmatic nucleus (SCN), and peripheral clocks in immune cells by linked transcriptional and/or translational feedback loops involving so-called clock genes. Circadian regulation of TLR9 function allows for an optimal timing of immune intervention such as vaccination and immunotherapy. Immunity 2012 36, 159-161DOI: (10.1016/j.immuni.2012.02.003) Copyright © 2012 Elsevier Inc. Terms and Conditions

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