Dialing in EGFR Signaling

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Dialing in EGFR Signaling Eileen J. Kennedy, Natarajan Kannan Chemistry & Biology Volume 22, Issue 6, Pages 687-688 (June 2015) DOI: 10.1016/j.chembiol.2015.06.001 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 The Rotational Influence of the Juxtamembrane on EGFR Activity Upon growth factor binding and receptor dimerization, juxtamembrane-A (JM-A) forms a coiled coil. Depending on which growth factor binds the receptor, the JM-A helices can rotate relative to one another to form distinct active coiled coil conformations. These rotational changes may act as a regulatory mechanism for downstream signaling. A sequence alignment of the JM region is shown for EGFR orthologs from diverse organisms and from across the ErbB family in humans. Nematodes and flies notably lack multiple conserved acidic and basic residues in JM-A. The “other” category includes three species: Aplysia californica, Metaseiulus occidentalis, and Strongylocentrotus purpuratus. Chemistry & Biology 2015 22, 687-688DOI: (10.1016/j.chembiol.2015.06.001) Copyright © 2015 Elsevier Ltd Terms and Conditions