Ada G. Blidner, Karina V. Mariño, Gabriel A. Rabinovich Immunity

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Driving CARs into Sweet Roads: Targeting Glycosylated Antigens in Cancer Ada G. Blidner, Karina V. Mariño, Gabriel A. Rabinovich Immunity Volume 44, Issue 6, Pages 1248-1250 (June 2016) DOI: 10.1016/j.immuni.2016.06.010 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Selective Recognition of the Tumor-Associated Hypoglycosylated Forms Tn-STn on MUC-1 by T Cells Engineered to Express the Chimeric Antigen Receptor 5E5 In the absence of the molecular chaperone COSMC (required for stability of the C1GalT1 glycosyltransferase), exposure of the Tn-STn glycoepitope on MUC-1 is favored, leading to selective recognition of tumor cells by 5E5 CAR-T cells. In contrast, sustained expression of COSMC inhibits exposure of these hypoglycosylated epitopes, preventing cytotoxicity induced by engineered 5E5 CAR-T cells. Immunity 2016 44, 1248-1250DOI: (10.1016/j.immuni.2016.06.010) Copyright © 2016 Elsevier Inc. Terms and Conditions