Entry Task Apply: Suppose a template strand of DNA had the following sequence: DNA: T A C G G A T A A C T A C C G G G T A T T C A A What would.

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Entry Task Apply: Suppose a template strand of DNA had the following sequence: DNA: T A C G G A T A A C T A C C G G G T A T T C A A What would be the complementary strand of mRNA? RNA: A U G C C U AU U G A U G G C C C A U A A G U U

Translate! Met Pro Ile Asp Gly Pro Stop RNA: A U G | C C U | A U U | G A U | G G C | C C A | U A A | G U U Met Pro Ile Asp Gly Pro Stop Translate! Convert your RNA sequence to Amino Acids

Types of Mutations Wild-type (normal version of gene) Silent Mutation (no effect on amino acid) Missense Mutation (changes an amino acid) Nonsense Mutation (premature stop codon) Frameshift Mutation (InDel) Insertion Mutation (one or more DNA bases are added to a sequence, potentially resulting in all new amino acids) Deletion Mutation (one or more DNA bases are deleted from a sequence, potentially resulting in all new amino acids)

T A C G G C T A A C T A C C G G G T A T T C A A Silent Mutation T A C G G A T A A C T A C C G G G T A T T C A A A U G C C U A U U G A U G G C C C A U A A G U U Met Pro Ile Asp Gly Pro Stop T A C G G C T A A C T A C C G G G T A T T C A A A U G | C C G | A U A | G A U | G G C | C C U | U A A | G U U Met Pro Ile Asp Gly Pro Stop

Missense Mutation T A C G G A T A A C T A C C G G G T A T T C A A A U G C C U A U U G A U G G C C C A U A A G U U Met Pro Ile Asp Gly Pro Stop T A C C G A T A A C T A C C G G G T A T T C A A A U G | G C U | A U A | G A U | G G C | C C U | U A A | G U U Met Ala Ile Asp Gly Pro Stop

T A C A T T T A A C T A C C G G G T A T T C A A Missense Mutation T A C G G A T A A C T A C C G G G T A T T C A A T A C A T T T A A C T A C C G G G T A T T C A A A U G | U A A | A U A G A U G G C C C U U A A G U U Met Stop

T A C G A G A T A A C T A C C G G G T A T T C A A Frameshift Mutation T A C G G A T A A C T A C C G G G T A T T C A A A U G C C U A U U G A U G G C C C A U A A G U U Met Pro Ile Asp Gly Pro Stop T A C G A G A T A A C T A C C G G G T A T T C A A A U G | C U C | G A U | A G A | U G G | C C C | U U A | A G U | U Met Leu Asp Arg Trp Pro Leu Ser