Omega 3 – Omega 6: What is right for the liver? Ashraf Mohammad El-Badry, Rolf Graf, Pierre-Alain Clavien  Journal of Hepatology  Volume 47, Issue 5, Pages 718-725 (November 2007) DOI: 10.1016/j.jhep.2007.08.005 Copyright © 2007 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Eicosanoid synthesis from dihomo-γ-linoleic acid (DGLA), arachidonic acid and eicosapentaenoic acid (EPA). LT, leukotriene; PG, prostaglandin; TX, thromboxane (modified from: Simopoulos AP. World Rev Nutr Diet 2003;92:1–22). Journal of Hepatology 2007 47, 718-725DOI: (10.1016/j.jhep.2007.08.005) Copyright © 2007 European Association for the Study of the Liver Terms and Conditions

Fig. 2 PUFA-mediated lipid accumulation in the liver which possibly influences the histological pattern of hepatic steatosis. ACO, acyl-CoA oxidase; apo B-100, apolipoprotein B-100; CPT-1, carnitine palmitoyl transferase-1; FAS, fatty acid synthase; NF-Y, nuclear factor-Y; PPAR-α, peroxisome proliferator activated receptor-α; SCD-1, stearoyl Co-A desaturase-1; SREBP-1, sterol regulatory element binding protein-1. Journal of Hepatology 2007 47, 718-725DOI: (10.1016/j.jhep.2007.08.005) Copyright © 2007 European Association for the Study of the Liver Terms and Conditions