Role of HIPK2 in kidney fibrosis

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Role of HIPK2 in kidney fibrosis Ying Fan, Niansong Wang, Peter Chuang, John C. He Kidney International Supplements Volume 4, Issue 1, Pages 97-101 (November 2014) DOI: 10.1038/kisup.2014.18 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Schema on the combined experimental and computational approach to characterize signaling pathway activation in HIV-associated nephropathy. EMT, epithelial–mesenchymal transition; HIPK2, homeodomain interacting protein kinase 2; KEA, kinase enrichment analysis; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; PPI, protein–protein interactions; TFs, transcription factors; TGF, transforming growth factor; WT, wild type. Kidney International Supplements 2014 4, 97-101DOI: (10.1038/kisup.2014.18) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 2 Schematic summary of HIPK2-interacting domains. AID, auto-inhibitory domain; HID, homeobox-interacting domain; KD, kinase domain; PEST, a peptide sequence that is rich in proline (P), glutamic acid (E), serine (S), and threonine; SIM, SUMO-interacting motif; SRS, speckle-retention signal; SUMO, sumoylation; Ub, ubiquitylation. Kidney International Supplements 2014 4, 97-101DOI: (10.1038/kisup.2014.18) Copyright © 2014 International Society of Nephrology Terms and Conditions