New Antithrombotic Drugs

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Presentation transcript:

New Antithrombotic Drugs Jeffrey I. Weitz, MD, FCCP, John W. Eikelboom, MBBS, Meyer Michel Samama, MD CHEST Volume 141, Issue 2, Pages e120S-e151S (February 2012) DOI: 10.1378/chest.11-2294 Copyright © 2012 The American College of Chest Physicians Terms and Conditions

Figure 1 New antiplatelet drugs. PAR = protease-activated receptor. CHEST 2012 141, e120S-e151SDOI: (10.1378/chest.11-2294) Copyright © 2012 The American College of Chest Physicians Terms and Conditions

Figure 2 Sites of action of new anticoagulants in more advanced stages of development. NAPc2 = nematode anticoagulant peptide c2. CHEST 2012 141, e120S-e151SDOI: (10.1378/chest.11-2294) Copyright © 2012 The American College of Chest Physicians Terms and Conditions

Figure 3 Classification of new anticoagulants. Indirect anticoagulants act in an AT-dependent fashion or exert their effect via the protein C pathway. Direct anticoagulants do not require a plasma cofactor. Instead, these agents directly target a specific coagulation enzyme. AT = antithrombin. See Figure 2 legend for expansion of other abbreviation. CHEST 2012 141, e120S-e151SDOI: (10.1378/chest.11-2294) Copyright © 2012 The American College of Chest Physicians Terms and Conditions