Supplemental Figure 4. Probiotics increased enterocyte migration and proliferation in a strain-specific manner in rotavirus-infected overweight mice. A,

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Supplemental Figure 4. Probiotics increased enterocyte migration and proliferation in a strain-specific manner in rotavirus-infected overweight mice. A, Immunohistochemistry for BrdU at different times after injection. Graphs show mean position (+ SD) of foremost and least-progressed BrdU-labeled enterocytes (n = 7 mice per group). B, Proliferation of crypt cells, determined 4 hours post-BrdU (n = 15 mice per group; mean + SD). C, Crypt height at various times post-BrdU (n = 7 mice per group; mean + SD). *P < .05, **P < .01, and ***P < .001 versus PBS controls; #P < .05, ##P < .01, and ###P < .001 between strains; hpi, hours post-injection; dpi, days post-injection; L. reuteri strains were designated as 17938 and 6475; all images captured at 200X magnification.

A PBS 17938 6475 4 hpi 24 hpi 2 dpi 3 dpi 4 dpi B C