Bayesian network meta-analysis of nitinol stents, covered stents, drug-eluting stents, and drug-coated balloons in the femoropopliteal artery Konstantinos.

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Bayesian network meta-analysis of nitinol stents, covered stents, drug-eluting stents, and drug-coated balloons in the femoropopliteal artery Konstantinos Katsanos, MSc, MD, PhD, EBIR, Stavros Spiliopoulos, MD, PhD, EBIR, Narayan Karunanithy, MRCS, FRCR, EBIR, Miltiadis Krokidis, MD, PhD, EBIR, Tarun Sabharwal, FRCR, EBIR, Peter Taylor, MA, MChir, FRCS Journal of Vascular Surgery Volume 59, Issue 4, Pages 1123-1133.e8 (April 2014) DOI: 10.1016/j.jvs.2014.01.041 Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 1 Trial selection process according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement. Journal of Vascular Surgery 2014 59, 1123-1133.e8DOI: (10.1016/j.jvs.2014.01.041) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 2 Detailed analysis of the risk of bias of each included randomized controlled trials (RCTs) according to the Cochrane Collaboration Tool. Journal of Vascular Surgery 2014 59, 1123-1133.e8DOI: (10.1016/j.jvs.2014.01.041) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 3 Mixed treatment comparison (MTC) network of evidence. The straight lines denote direct head-to-head comparisons and the dotted lines denote indirect comparisons in which direct comparison data are missing. The numbers next to the solid lines refer to the number of randomized controlled trials (RCTs), with direct comparisons available for each link. Journal of Vascular Surgery 2014 59, 1123-1133.e8DOI: (10.1016/j.jvs.2014.01.041) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 4 Condensed network of evidence in the case of technical success analysis. The straight lines denote direct head-to-head comparisons and the numbers next to the solid lines refer to the number of randomized controlled trials (RCTs), with direct comparisons available for each link. Journal of Vascular Surgery 2014 59, 1123-1133.e8DOI: (10.1016/j.jvs.2014.01.041) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 5 Rankograms of the cumulative ranking probabilities for (A) technical success, (B) vascular restenosis, and (C) for target lesion revascularization (TLR). On the horizontal axis is the possible rank of each option, based on relative efficacy (first best to last worse). On the vertical axis is the cumulative probability of each treatment per rank (probability to be the first, second, third, etc, best option). The larger the area under the cumulative probability ranking curve the better the treatment compared with the rest.21 Journal of Vascular Surgery 2014 59, 1123-1133.e8DOI: (10.1016/j.jvs.2014.01.041) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 6 Random-effects Forest plot of pooled estimates of technical success for the condensed network of evidence. The black lines denote 95% credible intervals (CrIs) and the gray lines denote 95% prediction intervals. The numbers represent odds ratios (ORs) and 95% CrIs. Journal of Vascular Surgery 2014 59, 1123-1133.e8DOI: (10.1016/j.jvs.2014.01.041) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 7 Random-effects Forest plot of pooled estimates of vascular restenosis. The black lines denote 95% credible intervals (CrIs) and the gray lines denote 95% prediction intervals. The numbers represent odds ratios (ORs) and 95% CrIs. BA, Balloon angioplasty; BNS, bare nitinol stent; CNS, covered nitinol stent; PCB, paclitaxel-coated balloon; PES, paclitaxel-eluting stent; SES, sirolimus-eluting stent. Journal of Vascular Surgery 2014 59, 1123-1133.e8DOI: (10.1016/j.jvs.2014.01.041) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 8 Random-effects Forest plot of pooled estimates of target lesion revascularization (TLR). The black lines denote 95% credible intervals (CrIs) and the gray lines denote 95% prediction intervals. The numbers represent odds ratios (ORs) and 95% CrIs. BA, Balloon angioplasty; BNS, bare nitinol stent; CNS, covered nitinol stent; PCB, paclitaxel-coated balloon; PES, paclitaxel-eluting stent; SES, sirolimus-eluting stent. Journal of Vascular Surgery 2014 59, 1123-1133.e8DOI: (10.1016/j.jvs.2014.01.041) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 9 Meta-regression plots of effect summaries against the baseline risk of events for (A) technical success, (B) vascular restenosis, and (C) for target lesion revascularization (TLR). Outcomes in favor of the active treatment are denoted with log(OR) >0 in the case of technical success and log(OR) <0 in the case of vascular restenosis and TLR. Pooled effect summaries in the present meta-analysis were reported on the mean covariate value of plain balloon angioplasty denoted by the dotted vertical lines in all cases.19 Journal of Vascular Surgery 2014 59, 1123-1133.e8DOI: (10.1016/j.jvs.2014.01.041) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 10 Forest plot of network consistency analysis for comparisons, with n ≥ 3 trials. Numbers represent the posterior means and standard deviations (SDs) of the direct, indirect, and overall mixed treatment comparison (MTC) estimates of the odds ratios (ORs) and rate ratios (RRs). BA, Balloon angioplasty; BNS, bare nitinol stent; CNS, covered nitinol stent; PCB, paclitaxel-coated balloon; PES, paclitaxel-eluting stent; SES, sirolimus-eluting stent. Journal of Vascular Surgery 2014 59, 1123-1133.e8DOI: (10.1016/j.jvs.2014.01.041) Copyright © 2014 Society for Vascular Surgery Terms and Conditions