Organogenesis of the endocrine pancreas

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Presentation transcript:

Organogenesis of the endocrine pancreas Marc R. Hammerman  Kidney International  Volume 68, Issue 5, Pages 1953-1955 (November 2005) DOI: 10.1111/j.1523-1755.2005.00628.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Photographs of embryonic (E) day E28 pig pancreas. (A) The dorsal pancreas (dp), the ventral pancreas (vs), and duodenum (duo) are shown in this untampered pancreas. (B) Day E28 pig pancreas 3 weeks after implantation in the omentum of a host rat. The fat accumulation is shown (arrow). Magnifications are shown. Reproduced with permission[8]. Kidney International 2005 68, 1953-1955DOI: (10.1111/j.1523-1755.2005.00628.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Photographs (A and B) and photomicrographs (C to G) of omentum from diabetic rats. (A) Omentum from a rat that underwent sham transplantation 20 weeks previously. (B) Omentum from a rat into which five pig pancreatic anlagen had been transplanted 20 weeks previously (arrows delineate fat). (C) Hematoxylin and eosin-stained section of omentum from a Lewis rat into which 10 Lewis rat pancreatic anlagen had been transplanted 20 weeks previously. (D) Hematoxylin and eosin-stained section of omentum from a rat into which five pig pancreatic anlagen had been transplanted 20 weeks previously. Arrowheads delineate flattened nuclei, arrows, rounded nuclei. (E to G) Sections of omentum from a Lewis rat into which five pig pancreatic anlagen had been transplanted 20 weeks previously. (E) A control antibody-stained section. (F) An anti-insulin antibody-stained section. (G) A combined Gomori-stained section. Arrows delineate cells. Magnification is shown in (B) [for (A) and (B)], (D) [for (C and (D)], and in (G) [for (E) to (G)]. Reproduced with permission[8]. Kidney International 2005 68, 1953-1955DOI: (10.1111/j.1523-1755.2005.00628.x) Copyright © 2005 International Society of Nephrology Terms and Conditions