Some DCs Are “B”etter Immunity

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Some DCs Are “B”etter Immunity Brian Ruffell, Lisa M. Coussens  Immunity  Volume 38, Issue 4, Pages 626-628 (April 2013) DOI: 10.1016/j.immuni.2013.03.011 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Intratumoral Antigen Presentation by CD11b+Ly6C+ DCs following Anthracycline-Induced ICD Anthracyclines induce ICD in sensitive cells, leading to release of ATP and recruitment of CD11b+Ly6C+ inflammatory monocytes via purinergic receptors. ATP also promotes DC differentiation, and following antigen uptake and activation via the interaction between HMGB1 and TLR4, CD11b+Ly6C+ DCs remain in the tumor and are able to promote a local CD8+ T cell response. Immunity 2013 38, 626-628DOI: (10.1016/j.immuni.2013.03.011) Copyright © 2013 Elsevier Inc. Terms and Conditions

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