Benefit-risk balance. Benefit-risk balance. Predicted probabilities of developing serious infection versus predicted probabilities of achieving Boolean-based remission. Patients were divided into 9 areas (A–I). Numbers of patients in each area were 90 for A, 1628 for B, 1742 for C, 1 for D, 144 for E, 635 for F, 1 for G, 28 for H, and 335 for I. Functions: Area A = Y ≥ 0.4542 and X < 0.0377; Area I = Y < 0.1514 and X ≥ 0.0754. Takao Koike et al. J Rheumatol 2014;41:15-23 ©2014 by The Journal of Rheumatology