Identification of a PVL-negative SCCmec-IVa sublineage of the methicillin-resistant Staphylococcus aureus CC80 lineage: understanding the clonal origin.

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Identification of a PVL-negative SCCmec-IVa sublineage of the methicillin-resistant Staphylococcus aureus CC80 lineage: understanding the clonal origin of CA-MRSA S.M. Edslev, H. Westh, P.S. Andersen, R. Skov, N. Kobayashi, M.D. Bartels, F. Vandenesch, A. Petersen, P. Worning, A.R. Larsen, M. Stegger Clinical Microbiology and Infection Volume 24, Issue 3, Pages 273-278 (March 2018) DOI: 10.1016/j.cmi.2017.06.022 Copyright © 2017 The Author(s) Terms and Conditions

Fig. 1 Maximum likelihood phylogeny of CC80 Staphylococcus aureus lineage. Phylogeny is based on 4868 single-nucleotide polymorphisms in core genome and reveals three distinct clades of lineage: Sub-Saharan African MSSA clade, European CA-MRSA clade and novel MSRA clade. Clades are marked with shades of grey. Information on selected genetic markers includes: carriage of SCCmec type IVa (light blue) or IVc (dark blue), carriage of PVL-encoding genes lukS/F-PV (purple) and carriage of fusB (green). Isolate IDs referred to in text are bold. CA, community acquired; CC, clonal complex; MRSA, methicillin-resistant S. aureus; MSSA, methicillin-susceptible S. aureus; PVL, Panton-Valentine leukocidin; SCCmec, staphylococcal cassette chromosome mec. Clinical Microbiology and Infection 2018 24, 273-278DOI: (10.1016/j.cmi.2017.06.022) Copyright © 2017 The Author(s) Terms and Conditions