A technique for dating toxoplasmosis in pregnancy and comparison with the Vidas anti- toxoplasma IgG avidity test P. Flori, B. Bellete, C. Crampe, A.

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Presentation transcript:

A technique for dating toxoplasmosis in pregnancy and comparison with the Vidas anti- toxoplasma IgG avidity test P. Flori, B. Bellete, C. Crampe, A. Maudry, H. Patural, C. Chauleur, J. Hafid, H. Raberin, R. Tran Manh Sung Clinical Microbiology and Infection Volume 14, Issue 3, Pages 242-249 (March 2008) DOI: 10.1111/j.1469-0691.2007.01905.x Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Evolution of the Axsym IgG/Access IgG ratio, based on the time between infection and sampling, for 384 selected sera. Correlation between the ratio and time between infection and sampling was r = –0.59 (p <0.001). The three circled sera came from the same pregnant woman. aPreg, pregnancy; bID, immunodepressed; cID+React, ID with reactivation. Clinical Microbiology and Infection 2008 14, 242-249DOI: (10.1111/j.1469-0691.2007.01905.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Evolution of the Toxo-IgG avidity Vidas results, based on the time between infection and sampling, for 384 selected sera. Correlation between Toxo-IgG avidity index and time between infection and sampling: r = 0.90 (p <0.001). aPreg, pregnancy; bID, immunodepressed; cID+React, ID with reactivation. Clinical Microbiology and Infection 2008 14, 242-249DOI: (10.1111/j.1469-0691.2007.01905.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 3 Proposed algorithm for the follow-up of pregnant women presenting with anti-Toxoplasma IgM and IgG in the first serum. (*denotes the percentage of pregnant women (n = 4000) with this profile at the onset of pregnancy in our laboratory). Clinical Microbiology and Infection 2008 14, 242-249DOI: (10.1111/j.1469-0691.2007.01905.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions