Receptori za antigen na limfocitima

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Presentation transcript:

Receptori za antigen na limfocitima

Receptori za prepoznavanje Urođena imunost Prepoznavanje: molekulski obrazci Geni: funkcionalni i identični u svim ćelijama Raspored: jedna ćelija iskazuje više kopija različitih receptora za prepoznavanje Distribucija: neklonska distribucija (isti receptor na svim ćelijama jedne ili više ćelijskih linija) Stečena imunost (T i B limfociti) Prepoznavanje: strukturni detalji molekula (antigenske determinante) Geni: postaju funkcionalni nakon rekombinacije genskih segmenata Raspored: jedna ćelija iskazuje više kopija jednog receptora za prepoznavanje Distribucija: klonska distribucija (ćelije jednog klona imaju receptor iste specifičnosti)

Antigenski receptori na limfocitima – sličnosti Nalaze se na membrani limfocita

Antigenski receptori na limfocitima – sličnosti Ig domeni Nalaze se na membrani limfocita Pripadaju superfamiliji imunoglobulinskih molekula (domenska struktura)

Antigenski receptori na limfocitima – sličnosti Nalaze se na membrani limfocita Pripadaju superfamiliji imunoglobulinskih molekula (domenska struktura) Dva različita lanca ulaze u sastav molekula

Antigenski receptori na limfocitima – sličnosti Nalaze se na membrani limfocita Pripadaju superfamiliji imunoglobulinskih molekula (domenska struktura) Dva različta lanca ulaze u sastav molekula Varijabilni delovi su u kontaktu sa antigenom (kodirani rekombinovanom DNK)

Antigenski receptori na limfocitima – sličnosti Aktivacioni motiv Disulfidna veza Nalaze se na membrani limfocita Pripadaju superfamiliji imunoglobulinskih molekula (domenska struktura) Dva različta lanca ulaze u sastav molekula Varijabilni delovi su u kontaktu sa antigenom (kodirani rekombinovanom DNK) Pridruženi molekuli za sprovođenje signala

Antigenski receptori na limfocitima – razlike Prepoznaje: Slobodne antigene (ali i membranske) Proteine, polisaharide, lipide DNK, RNK Konformacione i linearne epitope Prepoznaje: Kompleks na membrani druge ćelije Samo peptide αβ TCR (γδ i lipide) Linearne epitope

Antigenski receptori na limfocitima – razlike Prepoznaje: Slobodne antigene (ali i membranske) Proteine, polisaharide, lipide DNK, RNK Konformacione i linearne epitope Sastoji se od: 4 polipeptidna lanca (2 teška i 2 laka) Prepoznaje: Kompleks na membrani druge ćelije Samo peptide (αβ TCR) Linearne epitope Sastoji se od: 2 polipeptidna lanca (αβ ili γδ)

Građa antitela Membransko Sekretovano Membrana B limfocita

Građa antitela Vezna mesta za antigen Laki lanac Teški lanac Disulfidne veze

Građa antitela – digestija papainom Vezivanje antigena Fab fragmenti Region zgloba Papain Fc fragment Saradnja sa drugim komponentama imunskog sistema (ćelije, komplement)

Građa antitela – digestija pepsinom Vezivanje antigena F(ab)2 fragment Pepsin

Nobelova nagrada za fiziologiju i medicinu 1972 Gerald M. Edelman Rodney R. Porter "for their discoveries concerning the chemical structure of antibodies"

MHC-Peptid-TCR kompleks Aminokiselina koja stupa u kontakt sa TCR-om Polimorfni delovi MHC molekula Sidarne aminokiseline Džep MHC molekula Peptid

Koreceptorski molekuli BCR TCR Prepoznavanje bez učešća drugih molekula Prepoznavanje peptid-MHC kompleksa od strane TCR zahteva CD4/CD8 koreceptor