Divergent effects of a combined hormonal oral contraceptive on insulin sensitivity in lean versus obese women  Kai I. Cheang, Pharm.D., M.S., Paulina A. Essah, M.D., M.S., Susmeeta Sharma, M.B.B.S., Edmond P. Wickham, M.D., John E. Nestler, M.D.  Fertility and Sterility  Volume 96, Issue 2, Pages 353-359.e1 (August 2011) DOI: 10.1016/j.fertnstert.2011.05.039 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Insulin sensitivity assessments during 6 months of oral contraceptive administration in lean and obese groups (mean ± standard error of the mean). (A) Insulin sensitivity (Si) obtained from frequently sampled intravenous glucose tolerance test (FSIVGTT) at baseline and 6 months. (B) Matsuda index of insulin sensitivity obtained from oral glucose tolerance test at baseline, 3 and 6 months. (C) Insulin sensitivity index by homeostatic model assessment (ISI HOMA), using fasting glucose and insulin concentrations at baseline, 3 and 6 months. Lean and obese women exhibited statistically significantly different time trends in Si (P=.0494), Matsuda index (P=.0227), and ISI HOMA (P=.0128), during the 6 months of oral contraceptive use. Fertility and Sterility 2011 96, 353-359.e1DOI: (10.1016/j.fertnstert.2011.05.039) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions