Mammary Ductal Environment Is Necessary for Faithful Maintenance of Estrogen Signaling in ER+ Breast Cancer  Svasti Haricharan, Jonathan Lei, Matthew.

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Mammary Ductal Environment Is Necessary for Faithful Maintenance of Estrogen Signaling in ER+ Breast Cancer  Svasti Haricharan, Jonathan Lei, Matthew Ellis  Cancer Cell  Volume 29, Issue 3, Pages 249-250 (March 2016) DOI: 10.1016/j.ccell.2016.02.017 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Historical Perspective of Animal Models of ER+ Breast Cancer Timeline provides chronological context to the nearly 20-year-long refinement of animal models for the study of ER+ breast cancer, one of the leading contributors to cancer-related death worldwide. Animal models are broadly classified as mutagen-induced, genetically engineered, and xenografts, and brief descriptions of their principal characteristics and associated disadvantages are provided in the text blocks below each classification. DMBA, 7,12-dimethylbenz(A)anthracene; E2, 17-beta-estradiol; ER, estrogen receptor; ESR1, estrogen receptor 1 gene; MIND, mouse intraductal model; PDX, patient-derived xenograft. Cancer Cell 2016 29, 249-250DOI: (10.1016/j.ccell.2016.02.017) Copyright © 2016 Elsevier Inc. Terms and Conditions

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