Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data David A Jolliffe, PhD,

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Presentation transcript:

Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data David A Jolliffe, PhD, Lauren Greenberg, MSc, Richard L Hooper, PhD, Prof Christopher J Griffiths, DPhil, Prof Carlos A Camargo, MD, Conor P Kerley, PhD, Megan E Jensen, PhD, Prof David Mauger, PhD, Prof Iwona Stelmach, PhD, Prof Mitsuyoshi Urashima, MD, Prof Adrian R Martineau, PhD The Lancet Respiratory Medicine Volume 5, Issue 11, Pages 881-890 (November 2017) DOI: 10.1016/S2213-2600(17)30306-5 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Study selection The Lancet Respiratory Medicine 2017 5, 881-890DOI: (10.1016/S2213-2600(17)30306-5) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 2 Two-step individual participant data meta-analysis, event rate for asthma exacerbations requiring treatment with systemic corticosteroids Weights are from the random-effects analysis. No asthma exacerbations requiring treatment with systemic corticosteroids arose in the trials by Urashima and colleagues9 and Majak and colleagues.10 Only one such event arose in the trial by Tachimoto and colleagues;14 as such, an adjusted incidence rate ratio could not be calculated for this study. The Lancet Respiratory Medicine 2017 5, 881-890DOI: (10.1016/S2213-2600(17)30306-5) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 3 Effects of vitamin D supplementation on asthma exacerbation rate by baseline circulating 25(OH)D concentration categorised by 25 nmol/L strata Shown are the results of one-step individual participant data meta-analysis. The incidence rate ratio is adjusted for age and sex. Mean and 95% CI are presented. 25(OH)D=25-hydroxyvitamin D. The Lancet Respiratory Medicine 2017 5, 881-890DOI: (10.1016/S2213-2600(17)30306-5) Copyright © 2017 Elsevier Ltd Terms and Conditions