Development of Heritable Melanoma in Transgenic Mice

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Development of Heritable Melanoma in Transgenic Mice Hua Zhu, Kenneth Reuhl, Xin Zhang, Rosanne Botha, Kevin Ryan, Joyce Wei, Suzie Chen Journal of Investigative Dermatology Volume 110, Issue 3, Pages 247-252 (March 1998) DOI: 10.1046/j.1523-1747.1998.00133.x Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Transgenic mice. (A) Tumors on the perianal region of a 1-y-old transgenic mouse at stage 4. (B) Tumors on the ear, eye, and snout of an 8- mo old transgenic mouse at stage 3. Journal of Investigative Dermatology 1998 110, 247-252DOI: (10.1046/j.1523-1747.1998.00133.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Histopathologic evaluation of transgenic mice. (A) Light micrograph of 5 μm sections of tumor from the perianal region from a 6 mo old mouse at stage 3. Accumulation of large, densely pigmented cells was observed within the dermis but sparing the epidermis. (B) Treatment of specimen from (A) following chemical bleaching of melanin. Nuclear detail is now visible, revealing large oval nuclei with prominent nucleoli. Mitotic figures were infrequent. (C) Cervical lymph node of a 5 mo old stage 3 mouse. Densely pigmented tumor cells formed nests, most evident at the periphery of the node. (D) Skeletal muscle from a stage 2 mouse at 7 mo of age. Infiltration of tumor cells between the muscle fibers is apparent. Scale bar, 100 μm (hematoxylin and eosin). Journal of Investigative Dermatology 1998 110, 247-252DOI: (10.1046/j.1523-1747.1998.00133.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Histopathologic evaluation of transgenic mice. (A) A metastatic pigmented tumor in the lung of a 4 mo old mouse at stage 3. (B) Heavily pigmented cellular aggregation in the interstitial space of the choroid plexus of the brain from a 6 mo old mouse at stage 3. The overlying choroid epithelium is not involved. (C) and (D) Ocular lesions in a 7 mo old mouse at stage 1. (C) Pigmented cells have proliferated in the interstitial space of the Harderian gland. (D) Hypercellularity of heavily pigmented round cells in the choroid layer of the eye Retinal epithelium remained intact. Scale bars, 100 μm (hematoxylin and eosin). Journal of Investigative Dermatology 1998 110, 247-252DOI: (10.1046/j.1523-1747.1998.00133.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Electron micrograph from stage 2 lesion. Multiple membrane- bound melanosomes and premelanosomes are present within the cytoplasm. With progression of the lesion, neoplastic cells became filled with melanosomes, which displace and obscure other organelles. Scale bar, 5 μm. Journal of Investigative Dermatology 1998 110, 247-252DOI: (10.1046/j.1523-1747.1998.00133.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions