Volume 52, Issue 3, Pages (September 2007)

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Volume 52, Issue 3, Pages 760-768 (September 2007) FGFR3 Mutations and a Normal CK20 Staining Pattern Define Low-Grade Noninvasive Urothelial Bladder Tumours Johanna M.M. van Oers, Peter J. Wild, Maximilian Burger, Stefan Denzinger, Robert Stoehr, Elke Rosskopf, Ferdinand Hofstaedter, Ewout W. Steyerberg, Monika Klinkhammer-Schalke, Ellen C. Zwarthoff, Theodorus H. van der Kwast, Arndt Hartmann European Urology Volume 52, Issue 3, Pages 760-768 (September 2007) DOI: 10.1016/j.eururo.2007.01.009 Copyright © 2007 European Association of Urology Terms and Conditions

Fig. 1 Immunohistochemical staining with CK20. (A) Normal CK20 expression pattern in which only the superficial urothelial cells are positive. (B) Abnormal CK20 staining pattern, represented by CK20 expression in all cell layers. European Urology 2007 52, 760-768DOI: (10.1016/j.eururo.2007.01.009) Copyright © 2007 European Association of Urology Terms and Conditions

Fig. 2 Kaplan-Meier analyses for disease-specific survival – (A) FGFR3, (B) Ki-67, (C) TP53, and (D) CK20. European Urology 2007 52, 760-768DOI: (10.1016/j.eururo.2007.01.009) Copyright © 2007 European Association of Urology Terms and Conditions

Fig. 3 Combination of FGFR3 status and CK20 IHC compared to stage (A) and grade (B). mut=mutant FGFR3; wt=wild-type FGFR3; normal=normal CK20 staining pattern; abnormal=abnormal CK20 staining pattern. European Urology 2007 52, 760-768DOI: (10.1016/j.eururo.2007.01.009) Copyright © 2007 European Association of Urology Terms and Conditions