Rome IV: What Has Changed?

Rome IV IBS Subtypes

IBS Pathophysiology

Rome IV: Functional Constipation

Epidemiology and Burden of IBS and CIC

Barriers to Patient Care

Recurrent Abdominal Pain With Disordered Bowel Habits

History and Physical Examination for Lower GI Symptoms

Alarm Features for Organic Disorders

Recurrent Abdominal Pain With Disordered Bowel Habits

Diagnostic Testing for Suspected IBS, by Subtype

Blood-Based Biomarker for IBS-D: Comparisons of Anti-CdtB and Anti-Vinculin Antibodies Between IBS and IBD, Celiac and Controls

Increased Colonic Bile Acid Exposure in IBS 75 SeHCAT Values -- Rome II Subgroups

Increased Bile Acid Synthesis in IBS-D

Recurrent Abdominal Pain With Disordered Bowel Habits

Diagnosis of IBS in Primary Care Positive Strategy = Strategy of Exclusion

Management of Patients With IBS

Graded Approach to Treatment of IBS

Dietary and Lifestyle Considerations

FODMAPs: Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols

Fiber (Bulking) Therapy for IBS

Probiotics

Medical Therapy Considerations for IBS (Non-FDA Approved)

FDA-Approved Therapies for IBS

FDA-Approved Pharmacologic Options for CIC

Lubiprostone

Linaclotide

Plecanatide

Alosetron

Alosetron: FDA Indication

Prescribing Recommendations for Alosetron

Eluxadoline

Rifaximin

Conclusions and Q&A

Abbreviations

Abbreviations (cont)

Abbreviations (cont)