Relationship between Genotype and Phenotype Molecular Basis for Relationship between Genotype and Phenotype genotype DNA DNA sequence transcription RNA translation amino acid sequence protein function phenotype organism

The Ames Test Reveals Mutagenic Compounds Strain 1 - frameshift mutation Strain 2 - base substitution

Revertant colonies per culture plate. Ames Test Results1 Revertant colonies per culture plate. Treatment Control diethyl sulfate* ICR-191** TA1575 11 14,700 13 TA1578 25 450 TA1575 : his base substitution mutant TA1578 : his frameshift mutant * Highly toxic alkylating agent, occurs as colorless liquid with peppermint odor ** Acridine, colorless solid intercalating agent, known carcinogen 1 McCann et al., 1975. Proc. Natl. Acad. Sci. USA 72 979-983.

Relationship between Genotype and Phenotype Molecular Basis for Relationship between Genotype and Phenotype genotype DNA DNA sequence transcription RNA translation amino acid sequence protein function phenotype organism

Diploid Life Cycle vs. Haploid Life Cycle