Network Meta-analysis Shows Commercialized Subcutaneous and Sublingual Grass Products Have Comparable Efficacy Harold Nelson, MD, Shannon Cartier, MSc,

Slides:

Advertisements

Similar presentations

Double-Blind Placebo-Controlled Trial of Dapsone in Antihistamine Refractory Chronic Idiopathic Urticaria Matt Morgan, MD, Andrew Cooke, MD, Laura Rogers,

Advertisements

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

The Relationship Between a Specific IgE Level and Asthma Outcomes: Results from the National Health and Nutrition Examination Survey Whitney.

Mental Health Services Claims and Adult Onset Asthma in Ontario, Canada Teresa To, PhD, Kandace Ryckman, MPH, Jingqin Zhu, MSc, Devon Williams, MSc, Laura.

Diagnostic Accuracy of Inflammatory Markers for Diagnosing Occupational Asthma Geneviève Racine, Roberto Castano, MD, PhD, André Cartier, MD, Catherine.

Advances in Diagnosing Peanut Allergy

Allergen immunotherapy: A practice parameter third update

Treatment effect of sublingual immunotherapy tablets and pharmacotherapies for seasonal and perennial allergic rhinitis: Pooled analyses Stephen R. Durham,

Oral Phenylephrine HCl for Nasal Congestion in Seasonal Allergic Rhinitis: A Randomized, Open-label, Placebo-controlled Study Eli O. Meltzer, MD, Paul.

Aleena Banerji, MD, Kimberly G. Blumenthal, MD, MSc, Kenneth H

Treatment effect of sublingual immunotherapy tablets and pharmacotherapies for seasonal and perennial allergic rhinitis: Pooled analyses Stephen R. Durham,

Vitamin D Insufficiency and Asthma in a US Nationwide Study

Luciana Kase Tanno, MD, PhD, Moises A

Chronic rhinosinusitis: Potential new use for topical sulfasalazine

Subcutaneous Icatibant for the Treatment of Hereditary Angioedema Attacks: Comparison of Home Self-Administration with Administration at a Medical Facility

Complementary and Alternative Medicine in Allergy-Immunology: More Information is Needed Leonard Bielory, MD The Journal of Allergy and Clinical Immunology:

Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: A meta-analysis–based comparison Danilo Di.

Dennis K. Ledford, MD, Sally Wenzel, MD

Shyam Joshi, MD, David A. Khan, MD

Jennie Gane, MBChB (Hons), MSc, Roger Buckley, BM BCh, MA, FRCS

Marc Carrier, MD, MSc, Alok A

Desensitization to Chemotherapeutic Agents

Intramuscular Versus Intravenous Immunoglobulin Replacement Therapy and Measurement of Immunoglobulin Levels During Immunoglobulin Replacement Therapy

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

A Predictive Model for the Diagnosis of Allergic Drug Reactions According to the Medical History Beatriz Hierro Santurino, MD, PhD, Javier Mateos Conde,

An Infant with Atopic Dermatitis and Itching After Ingestion of Milk

Response to sublingual immunotherapy with grass pollen extract: Monotherapy versus combination in a multiallergen extract Sheila M. Amar, MD, Ronald.

Hendrik Nolte, MD, PhD, David I

Safety of Fluticasone Propionate Prescribed for Asthma During Pregnancy: A UK Population-Based Cohort Study Rachel A. Charlton, PhD, Julia M. Snowball,

Melkersson-Rosenthal Syndrome

Validation of the Pregnancy Asthma Control Test

Reply Journal of Allergy and Clinical Immunology

The Relationship Between a Specific IgE Level and Asthma Outcomes: Results from the National Health and Nutrition Examination Survey Whitney.

Advances in Diagnosing Peanut Allergy

Erythematous Candidiasis

Nonadherence to Asthma Treatment: Getting Unstuck

Impact of Adverse Event Solicitation on the Safety Profile of SQ House Dust Mite Sublingual Immunotherapy Tablet Hendrik Nolte, MD, PhD, David I. Bernstein,

Successful treatment of idiopathic angioedema with ecallantide

House Dust Mite Respiratory Allergy: An Overview of Current Therapeutic Strategies Moisés A. Calderón, MD, PhD, Jörg Kleine-Tebbe, MD, Allan Linneberg,

Aimee L. Speck, MD, Michael Hess, MSI, Alan P. Baptist, MD, MPH

Laura Cordova-Rivera, BPhty(Hons), Peter G. Gibson, MBBS, Paul A

Management of Difficult-to-Treat Atopic Dermatitis

Repeated Episodes of Anaphylaxis with Normal Serum Tryptase but Elevated Levels of Urinary Prostaglandin D2 Phillip Lieberman, MD The Journal of Allergy.

Penicillin Skin Testing Is a Safe and Effective Tool for Evaluating Penicillin Allergy in the Pediatric Population Stephanie J. Fox, MD, Miguel A. Park,

Change in Asthma Control Over Time: Predictors and Outcomes

Phillip Lieberman, MD, Michael Tankersley, MD

Double-Blind Placebo-Controlled Trial of Dapsone in Antihistamine Refractory Chronic Idiopathic Urticaria Matt Morgan, MD, Andrew Cooke, MD, Laura Rogers,

The Management of Eosinophilic Esophagitis

Phillip Lieberman, MD, David Golden, MD

Russell S. Traister, MD, PhD, Merritt L

Melkersson-Rosenthal Syndrome

Sequential Treatment Initiation with Timothy Grass and Ragweed Sublingual Immunotherapy Tablets Followed by Simultaneous Treatment Is Well Tolerated

Linda S. Cox, MD, Cheryl Hankin, PhD, Richard Lockey, MD

Efficacy of house dust mite sublingual immunotherapy tablet in North American adolescents and adults in a randomized, placebo-controlled trial Hendrik.

International Study of Risk-Mitigating Factors and In-Flight Allergic Reactions to Peanut and Tree Nut Matthew Greenhawt, MD, MBA, MSc, Fiona MacGillivray,

Neetu Talreja, MD, Richard F. Lockey, MD

Sinonasal Papillomas and Natural Killer–Cell Deficiency

Sharon Seth, MD, David A. Khan, MD

Cephalosporin Side Chain Cross-reactivity

Evaluation of Allergen Immunotherapy

Impact of Adverse Event Solicitation on the Safety Profile of SQ House Dust Mite Sublingual Immunotherapy Tablet Hendrik Nolte, MD, PhD, David I. Bernstein,

Reply The Journal of Allergy and Clinical Immunology: In Practice

Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years Ronald Dahl, MD,

Long-term clinical efficacy in grass pollen–induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet Stephen.

Yu-Chen Huang, MD, Ying-Chih Cheng, MD

Epinephrine (adrenaline) absorption from new-generation, taste-masked sublingual tablets: A preclinical study Ousama Rachid, BPharm, MSc, Mutasem M.

Reply Journal of Allergy and Clinical Immunology

Pedro Giavina-Bianchi, MD, PhD, Shih-Wen Huang, MD

Subcutaneous and sublingual immunotherapy for seasonal allergic rhinitis: A systematic review and indirect comparison Janine Dretzke, MSc, Angela Meadows,

Natural history of cow’s milk allergy

Presentation transcript:

Network Meta-analysis Shows Commercialized Subcutaneous and Sublingual Grass Products Have Comparable Efficacy Harold Nelson, MD, Shannon Cartier, MSc, Felicia Allen-Ramey, PhD, Simon Lawton, MD, Moises A. Calderon, MD The Journal of Allergy and Clinical Immunology: In Practice Volume 3, Issue 2, Pages 256-266.e3 (March 2015) DOI: 10.1016/j.jaip.2014.09.018 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure 1 NMA practical approach. A, Network diagram: Dotted line indicates indirect comparison; solid line, direct comparison. B, NMA: Brief identification of steps involved in the estimation of comparisons in the network. Step 1: Data identified from the studies are pooled to estimate the treatment effects compared with placebo. Step 2: The relative treatment effects compared with placebo are then used to calculate the indirect comparisons. D, Drops; T, tablets. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, 256-266.e3DOI: (10.1016/j.jaip.2014.09.018) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure 2 Study selection flow diagram. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, 256-266.e3DOI: (10.1016/j.jaip.2014.09.018) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure 3 Direct comparison for symptom scores of immunotherapy treatment options versus placebo. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, 256-266.e3DOI: (10.1016/j.jaip.2014.09.018) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure 4 Direct comparison for medication scores of immunotherapy treatment options versus placebo. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, 256-266.e3DOI: (10.1016/j.jaip.2014.09.018) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure E1 Forest plots for symptom scores. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, 256-266.e3DOI: (10.1016/j.jaip.2014.09.018) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure E2 Funnel plots for each immunotherapy modality vs placebo. The funnel plots for SCIT symptom scores and SLIT-D symptom and medication scores appear to be sporadic. The funnel plots for SCIT medication scores, and SLIT-T symptom and medication scores, however, visually appear to have some asymmetry, lacking studies in the middle to lower section of the right-hand side of the funnel. D, Drops; T, tablets. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, 256-266.e3DOI: (10.1016/j.jaip.2014.09.018) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions