Myocardial protection with intermittent cold blood during aortic valve operation: antegrade versus retrograde delivery Attilio A Lotto, FRCS, Raimondo.

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Presentation transcript:

Myocardial protection with intermittent cold blood during aortic valve operation: antegrade versus retrograde delivery Attilio A Lotto, FRCS, Raimondo Ascione, MD, Massimo Caputo, MD, Alan J Bryan, FRCS, Gianni D Angelini, FRCS, M-Saadeh Suleiman, PhD The Annals of Thoracic Surgery Volume 76, Issue 4, Pages 1227-1233 (October 2003) DOI: 10.1016/S0003-4975(03)00840-3

Fig 1 Baseline (preischemic) concentrations of important metabolites in the normal right ventricle (hatched bars) compared with the hypertrophic left ventricle (open bars). Mean ± standard error. *p less than 0.05 compared with right ventricular biopsy. (ADP = adenosine diphosphate; Ala = alanine; AMP = adenosine monophosphate; ATP = adenosine triphosphate; Glu = glutamate.) The Annals of Thoracic Surgery 2003 76, 1227-1233DOI: (10.1016/S0003-4975(03)00840-3)

Fig 2 Concentrations (nmol/mg protein) of myocardial metabolites in ventricular biopsies from left and right ventricles of patients in the antegrade group, collected before ischemia (solid bars) and after reperfusion (open bars). Mean ± standard error *p less than 0.05 compared with corresponding value in control biopsy. (Ala/Glu = alanine-glutamate ratio; ATP = adenosine triphosphate.) The Annals of Thoracic Surgery 2003 76, 1227-1233DOI: (10.1016/S0003-4975(03)00840-3)

Fig 3 Concentrations (nmol/mg protein) of myocardial metabolites in ventricular biopsies from left and right ventricles of patients in the retrograde group, collected before ischemia (solid bars) and after reperfusion (open bars). Mean ± standard error *p less than 0.05 compared with corresponding value in control biopsy. **p less than 0.05 versus control and left ventricle. (Ala/Glu = alanine-glutamate ratio; ATP = adenosine triphosphate.) The Annals of Thoracic Surgery 2003 76, 1227-1233DOI: (10.1016/S0003-4975(03)00840-3)

Fig 4 Time-dependent postoperative release of troponin I (ng/mL) in both groups. Values are mean ± standard error. (Pre-op = preoperative.) The Annals of Thoracic Surgery 2003 76, 1227-1233DOI: (10.1016/S0003-4975(03)00840-3)