Tipping the balance from angiogenesis to fibrosis in CKD

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Presentation transcript:

Tipping the balance from angiogenesis to fibrosis in CKD Barbara J. Ballermann, Marya Obeidat Kidney International Supplements Volume 4, Issue 1, Pages 45-52 (November 2014) DOI: 10.1038/kisup.2014.9 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Mechanisms that contribute to the regression of the postglomerular capillary network when the glomerular circulation fails. Kidney International Supplements 2014 4, 45-52DOI: (10.1038/kisup.2014.9) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 2 Tissue hypoxia generates both angiogenic and fibrogenic signals. In chronic kidney disease, the balance is strongly shifted toward tissue fibrosis. CTGF, connective tissue growth factor; EMT, epithelial-to-mesenchymal transition; TGF-β1, transforming growth factor-beta 1. Kidney International Supplements 2014 4, 45-52DOI: (10.1038/kisup.2014.9) Copyright © 2014 International Society of Nephrology Terms and Conditions