The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients Stephen J Elledge, Angelika Amon Cancer.

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The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients Stephen J Elledge, Angelika Amon Cancer Cell Volume 1, Issue 2, Pages 129-132 (March 2002) DOI: 10.1016/S1535-6108(02)00041-7

Figure 1 A schematic representation of the BRCA1 suppressor hypothesis as an explanation for breast and ovarian tissue specificity of cancer in BRCA1 heterozygous individuals See text for explanation. LOH: loss of heterozygosity. Colored circles represent cells of particular genotypes. Changes in circle color indicate a change in genotype. Cancer Cell 2002 1, 129-132DOI: (10.1016/S1535-6108(02)00041-7)