Target recognition–induced NK-cell responses

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Target recognition–induced NK-cell responses by Xiaoli Zhang, and Jianhua Yu Blood Volume 115(11):2119-2120 March 18, 2010 ©2010 by American Society of Hematology

Schematic of CD56bright and CD56dim NK-cell cytokine and chemokine production upon target cell recognition and proinflammatory cytokine stimulation. Schematic of CD56bright and CD56dim NK-cell cytokine and chemokine production upon target cell recognition and proinflammatory cytokine stimulation. Upon target cell recognition, CD56dim NK cells produce increased levels of cytokines and chemokines compared with CD56bright NK cells. In contrast, CD56bright NK cells are the major cytokine producers when stimulated by proinflammatory cytokines (eg, IL-12, IL-15, and IL-18) or combinations thereof. Larger dots denote cytokine secretions, and smaller dots denote chemokine secretions. Xiaoli Zhang, and Jianhua Yu Blood 2010;115:2119-2120 ©2010 by American Society of Hematology