Signal Transduction Pathways and Cell Differentiation

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Presentation transcript:

Signal Transduction Pathways and Cell Differentiation Stem Cell Specialized cell type (neuron, skin cell, red blood cell, etc.)

Blood Cell Formation

Red Blood Cell Development

EPO Synthesis of proteins that stimulate Red Blood Cell development

Negative Regulation of JAK/STAT Pathway

Microtubules

Tubulin Dimer GTP GTP

Centrosome Structure

Pg. 583

Microtubule “Poisons” Colchicine Taxol (Autumn crocus) (Pacific Yew)

Tubulin Dimer GTP GTP Taxol

Microtubule “Motor” Proteins

Microtubule “Motor” Proteins

Microtubules Help to Organize the Cytoplasm

Actin Filaments

Actin Monomer

Arp2/3 (Actin Related Proteins)

Actin-GFP Actin Cable Cortical Actin Patch

Actin Cables and Actin Patches

Thrombin Resting Platlet Activated Platlet

Gelsolin Protein New minus end

Myosin-II

Muscle Cell

Sarcomere

Contraction of a Sarcomere

Resting Muscle