Figure 1 Overview of canonical TGF-β/Smad signalling in tissue fibrosis Figure 1 | Overview of canonical TGF-β/Smad signalling in tissue fibrosis. Once.

Slides:

Advertisements

Similar presentations

Gene Regulation in Eukaryotic Cells. Gene regulation is complex Regulation, and therefore, expression of a gene is complex. Regulation of these genes.

Advertisements

Signaling Pathways That Control Gene Activity TGFβ Receptors and the Direct Activation of Smads Presented By: Todd Lindsey.

Regulating Eukaryotic Gene Expression. Why change gene expression? Different cells need different components Responding to the environment Replacement.

Chapter 14: Signaling Pathways That Control Gene Activity

Chapter 18 – Gene Regulation Part 2

Fig. 3. Effects of lobeglitazone (Lobe) on transforming growth factor β (TGF-β)-induced profibrotic gene expression in cultured kidney cell lines. Representative.

Figure 1 Simplified scheme of TGFβ signalling

Figure 1. miRNA in NETs PNET SB-NET miR-7-5p miR-19a miR-96 miR-182

Copyright © 2015 by the American Osteopathic Association.

Figure. Schematic illustration on chitotriosidase (CHIT1) regulation of TGF-β pathway. CHIT1 enhances the effect of TGF-β through the induction of TGF-β.

Overview of the TGF-β signaling pathway

Regulation of Gene Expression

LncRNAs exert their effects by diverse mechanisms. LncRNAs exert their effects by diverse mechanisms. (A) lncRNAs can.

Figure 2 Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis Figure 2 | Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis.

Figure 3 LncRNAs in kidney disease

GENE REGULATION Key control mechanism for dictating cell phenotype

Mechanisms of lncRNA function.

Figure 1 The epigenetic landscape mediates the interplay between stressors and renal dysfunction Figure 1 | The epigenetic landscape mediates the interplay.

TGFb –Superfamily Proteins

Tendon Homeostasis: The Right Pull

Myocardin-Related Transcription Factors A and B Are Key Regulators of TGF-β1- Induced Fibroblast to Myofibroblast Differentiation Beverly J. Crider, George.

Nat. Rev. Endocrinol. doi: /nrendo

Figure 1 Intracellular regulation of the glucocorticoid receptor

Regulation of Gene Expression

Figure 1 The sensory and secretory function of the L cell

Coordinately Controlled Genes in Eukaryotes

Obstructive nephropathy: Insights from genetically engineered animals

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 Activation and signalling of IL-1

Figure 4 Potential therapeutic strategies to inhibit TGF-β1/Smad-induced tissue fibrosis Figure 4 | Potential therapeutic strategies to inhibit TGF-β1/Smad-induced.

Review Warm-Up What is the Central Dogma?

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 4 Immune regulatory roles of glycolytic intermediates

Nat. Rev. Nephrol. doi: /nrneph

mRNA Degradation and Translation Control

Figure 4 Diverse molecular mechanisms of long non-coding RNAs

Volume 46, Issue 5, Pages (June 2012)

Nat. Rev. Nephrol. doi: /nrneph

Activation of Adenylyl Cyclase Reduces TGF-β Profibrotic Response in Osteoarthritic Fibroblast-Like Synoviocytes M. Qadri, R. Ostrom, K.A. Elsaid Osteoarthritis.

Figure 4 Mechanisms of leptin function on kidney injury

Figure 3 Regulation of TGF-β1/Smad signalling by microRNAs (miRs) in tissue fibrosis Figure 3 | Regulation of TGF-β1/Smad signalling by microRNAs (miRs)

Wnt/β-catenin signaling and kidney fibrosis

Selective Insulin and Leptin Resistance in Metabolic Disorders

Targeting Smads to Restore Transforming Growth Factor-β Signaling and Regulatory T- Cell Function in Inflammatory Bowel Disease Deanna D. Nguyen, Scott.

Figure 1 Mechanistic classification of lncRNAs

T Cells Are Smad’ly in Love with Galectin-9

Long Noncoding RNA in Hematopoiesis and Immunity

Figure 2 A model of TNFR–complex I signalling

Proteins Kinases: Chromatin-Associated Enzymes?

Nitric oxide and vascular remodeling: Spotlight on the kidney

Figure 2 Histone acetylation regulates gene expression

CD4+ T cells: a potential player in renal fibrosis

Long Noncoding RNAs and Hepatocellular Carcinoma

Figure 3 Underlying mechanisms of TREG cells in atherosclerosis

A) Primary microRNA (pri-microRNA) is processed by Drosha in the nucleus to form pre-microRNA. a) Primary microRNA (pri-microRNA) is processed by Drosha.

Smad3 and Extracellular Signal-Regulated Kinase 1/2 Coordinately Mediate Transforming Growth Factor-β-Induced Expression of Connective Tissue Growth Factor.

Volume 76, Issue 5, Pages (September 2009)

Vladimir A. Botchkarev Journal of Investigative Dermatology

Figure 2 Signalling downstream of the IL-6 receptor

Model for TGF-β-induced myofibroblast differentiation involving MKL1 isoform-specific activities. Model for TGF-β-induced myofibroblast differentiation.

Volume 22, Issue 6, Pages (June 2014)

Nat. Rev. Rheumatol. doi: /nrrheum

Fibroblast responses to changes in miR-21-5p and miR-29 family levels

Stanley Nattel JACEP 2017;3:

The dynamic interplay between the lung extracellular matrix (ECM) and resident cells, with transforming growth factor (TGF)-β1 at its centre. The dynamic.

The canonical IFN-γ/JAK/STAT pathway.

Overview of molecular JAK signaling.

The Regulatory T Cell Transcriptosome: E Pluribus Unum

Predicting Risk of Radiation-Induced Lung Injury

Skp2, the FoxO1 hunter Cancer Cell

Presentation transcript:

Figure 1 Overview of canonical TGF-β/Smad signalling in tissue fibrosis Figure 1 | Overview of canonical TGF-β/Smad signalling in tissue fibrosis. Once released from the latency associated peptide (LAP)–latent TGF-β binding protein (LTBP) complex, the active homodimer form of TGF-β1 binds to TGF-β receptor 2 (TGFR2), which then recruits and activates TGFR1. The active TGFR1 then phosphorylates Smad2 and Smad3, which complex with Smad4 and translocate to the nucleus. The Smad3 component of the complex binds directly to gene promoters to induce transcription of profibrotic molecules, including α-smooth muscle actin (α-SMA), collagen I and tissue inhibitor of matrix metalloproteinases (TIMP), which induce myofibroblast activation and matrix deposition. In addition, Smad3 can induce transcription of profibrotic microRNA (miRNA) and long noncoding RNA (lncRNA), while acting indirectly to inhibit transcription of antifibrotic miRNAs. Finally, Smad3 can increase transcription of profibrotic molecules by influencing epigenetic modifications of DNA and histone proteins. Smad7 is a negative regulator of Smad2/3 and inhibits fibrosis. Meng, X.-m. et al. (2016) TGF-β: the master regulator of fibrosis Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.48