Heparin centenary – an ever-young life-saving drug Giangiacomo Torri, Annamaria Naggi  International Journal of Cardiology  Volume 212, Pages S1-S4 (June 2016) DOI: 10.1016/S0167-5273(16)12001-7 Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Schematic representation of the minimal binding sequences of heparin chain specific for some of the target proteins. Ans: (1–4) N-sulfated α-D glucosamine, ANS,6S: (1–4) N-sulfated,6-O-sulfated α-D-glucosamine, ANS,3,6S: (1–4) N-sulfated, 3-,6-O-sulfated α-D-glucosamine, G: (1–4) β-D-glucuronic acid, I: (1–4) α-L-Iduronic acid, I2S: (1–4) 2-O-sulfated α-L-iduronic acid. International Journal of Cardiology 2016 212, S1-S4DOI: (10.1016/S0167-5273(16)12001-7) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Simplified representation of the different way to produce the currently commercially available LMWHs and the structure of their characteristic main terminal residues. International Journal of Cardiology 2016 212, S1-S4DOI: (10.1016/S0167-5273(16)12001-7) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions