Chondrocyte moves: clever strategies? T.I. Morales, Ph.D.  Osteoarthritis and Cartilage  Volume 15, Issue 8, Pages 861-871 (August 2007) DOI: 10.1016/j.joca.2007.02.022 Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Individual chondrocyte videotracking. Example of a non-motile (panel A) and a motile cell (panel B). The cell images were captured at the times indicated. At each time, the shape of the cell is outlined. The cell at time 0 shows the superimposed outlines of the cell during subsequent movement captured from the individual frames shown in the different panels. The arrows show the direction of movement, and the inset on the lower right of each panel shows the cell trajectories. Copied from Chang et al.39 Osteoarthritis and Cartilage 2007 15, 861-871DOI: (10.1016/j.joca.2007.02.022) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Simplified diagram of proposed proliferative chondrocyte movements in the growth plate. This diagram was prepared by the author (T.I.M.) with the aid of the MGH photolab from information in video 1 and discussion of the paper by Aszodi et al.58, after consultation with Drs Aszodi and Hunziker. Osteoarthritis and Cartilage 2007 15, 861-871DOI: (10.1016/j.joca.2007.02.022) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Simplified diagram of hypothetical chondrocyte movements in the intervertebral disc. The diagram was prepared by the author (T.I.M.) with the aid of the MGH photolab from information in the papers from Kim et al.63,64, following consultation with Dr An. E = epiphysis; GP = growth plate. Note that the rabbit CE differed from what is reported for human CE. In humans, both the articular region and the growth plate are continuous in the CE. However, in rabbits, the articular region is separated gradually from the growth plate with the development of a secondary ossification center, an epiphysis62. Please see Ref.77 for an up to date review on the human intervertebral disc. Osteoarthritis and Cartilage 2007 15, 861-871DOI: (10.1016/j.joca.2007.02.022) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions