SUMOylation Places LRH-1 in PROXimity to Lipid Metabolism

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SUMOylation Places LRH-1 in PROXimity to Lipid Metabolism Christina Priest, Peter Tontonoz Cell Metabolism Volume 20, Issue 4, Pages 558-559 (October 2014) DOI: 10.1016/j.cmet.2014.09.008 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 SUMOylation of LRH-1 Promotes Its Interaction with PROX1 and Inhibits Gene Expression Linked to Reverse Cholesterol Transport LRH-1 promotes transcription of genes involved in hepatic reverse cholesterol transport including Scarb1, Abgc5, and Abcg8. Expression of these genes contributes to increased hepatic cholesterol uptake and excretion. SUMOylation of LRH-1 promotes its interaction with the transcriptional repressor PROX1 and thereby inhibits target gene expression, inhibits reverse cholesterol transport (RCT), and increases susceptibility to atherosclerosis. Cell Metabolism 2014 20, 558-559DOI: (10.1016/j.cmet.2014.09.008) Copyright © 2014 Elsevier Inc. Terms and Conditions